Document Detail

Dynamic Change of Hydrogen Sulfide After Traumatic Brain Injury and its Effect in Mice.
MedLine Citation:
PMID:  23325453     Owner:  NLM     Status:  Publisher    
Hydrogen sulfide (H(2)S) is a lipid-soluble, endogenously produced gaseous messenger molecule collectively known as gasotransmitter. Over the last several decades, gasotransmitters have emerged as potent cytoprotective mediators in various models of tissue and cellular injury. In this study, we performed a weight-drop traumatic brain injury (TBI) model in adult mice and investigated changes of H(2)S and its possible role in the pathogenesis after TBI. Expression of Cystathionine-β-synthase (CBS) mRNA as H(2)S-producing enzymes in mouse brain was determined by reverse transcriptase-polymerase chain reaction (RT-PCR). From the results of RT-PCR, it was found that the expression of CBS was down-regulated in mouse brain cortex and hippocampus after brain injury. Western blot analysis revealed that CBS was present in normal mouse brain cortex and the hippocampus. It gradually decreased, reached its lowest level and then increased. Hydrogen sulfide in the cortex and hippocampus exhibited dynamic changes after brain injury, in parallel with CBS mRNA and protein expression. Moreover, pretreatment with the H(2)S donor (NaHS) could protect the neuron against the injury induced by TBI. Noticeably, the H(2)S donor NaHS could reduce TBI-induced injury assessed with lesion volume. These data suggested that H(2)S may have a therapeutic potential against neuron damage.
Mingyang Zhang; Haiyan Shan; Tao Wang; Weili Liu; Yaoqi Wang; Long Wang; Lu Zhang; Pan Chang; Wenwen Dong; Xiping Chen; Luyang Tao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Neurochemical research     Volume:  -     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Forensic Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
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