Document Detail


Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression.
MedLine Citation:
PMID:  17077524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dykellic acid, a novel factor initially identified from the culture broth of Westerdykella multispora F50733, has been shown to inhibit matrix metalloprotease 9 activity, caspase-3 activity, B cell proliferation and LPS-induced IgM production, suggesting that this factor may have anti-cancer effects. In an effort to further address the possible anti-tumoral effects of dykellic acid, we used wound healing, invasion and RhoA-GTP assays to examine the effects of dykellic acid on cell migration, invasion and angiogenesis. Our results revealed that dykellic acid dose-dependently inhibits B16 cell migration and motility, and inhibits HUVEC tube formation. Western blot analysis of the active form of RhoA (RhoA-GTP) showed that dykellic acid treatment decreased the levels of RhoA-GTP. These findings collectively suggest that dykellic acid may have both anti-metastatic and anti-angiogenic acitivites, and provides the first evidence for the involvement of RhoA in dykellic acid-induced effects.
Authors:
Jin-Chul Heo; Ja-Young Park; Sang-Uk Woo; Jae-Rang Rho; Ho-Jae Lee; Sung-Uk Kim; Yung-Hee Kho; Sang-Han Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  29     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-01     Completed Date:  2007-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2256-9     Citation Subset:  IM    
Affiliation:
Department of Food Science & Technology, Kyungpook National University, Daegu, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessels / drug effects*,  physiology
Blotting, Western
Cell Line
Cell Line, Tumor
Cell Movement / drug effects*
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Endothelial Cells / drug effects,  physiology
Humans
Mice
Neoplasm Invasiveness / prevention & control
Neovascularization, Pathologic / metabolism,  prevention & control
Propionates / chemistry,  pharmacology*
Pyrones / chemistry,  pharmacology*
rhoA GTP-Binding Protein / metabolism*
Chemical
Reg. No./Substance:
0/Propionates; 0/Pyrones; 0/dykellic acid; EC 3.6.5.2/rhoA GTP-Binding Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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