| Dutasteride vs finasteride: assessment of differences in acute urinary retention rates and surgical risk outcomes in an elderly population aged > or =65 years. | |
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MedLine Citation:
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PMID: 18611089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine comparative differences on rates of acute urinary retention (AUR) and prostate-related surgeries among patients aged > or =65 years treated with dutasteride or finasteride. METHODS: For this retrospective analysis, medical/pharmacy claims data from July 1, 2003, to June 30, 2006, were analyzed for enlarged prostate patients aged > or =65 years treated with 5-alpha reductase inhibitors (5ARIs) regardless of alpha-blocker use. Charlson Comorbidity Index, Thomson Medstat Disease Staging, and propensity score matching techniques were used for comparative analysis. RESULTS: A total of 5090 patients met selection criteria. After 1 year of 5ARI therapy, the AUR rate was lower for dutasteride (12%) when compared with finasteride (14.7%) (odds ratio [OR], 0.79; P = .0042). Risks for prostate-related surgeries were also lower among dutasteride-treated patients (3.9% vs 5.1%, respectively; OR, 0.77; P = .03). CONCLUSION: Important therapeutic outcome differences exist between dutasteride and finasteride. Patients treated with dutasteride were significantly less likely to experience AUR and prostate-related surgeries than finasteride patients. |
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Authors:
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Thomas C Fenter; E Anne Davis; Manan B Shah; Pei-Jung Lin |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of managed care Volume: 14 ISSN: 1936-2692 ISO Abbreviation: Am J Manag Care Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-07-09 Completed Date: 2008-08-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9613960 Medline TA: Am J Manag Care Country: United States |
Other Details:
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Languages: eng Pagination: S154-9 Citation Subset: H |
Affiliation:
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University of Mississippi, Corporate Medical Advisor Blue Cross & Blue Shield of Mississippi, Jackson, MS, USA. dtcfms@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Aged, 80 and over Azasteroids / economics, therapeutic use* Enzyme Inhibitors / economics, therapeutic use* Finasteride / economics, therapeutic use* Humans Male Prostatectomy Prostatic Hyperplasia / complications*, drug therapy*, epidemiology, surgery Retrospective Studies Testosterone 5-alpha-Reductase / antagonists & inhibitors United States / epidemiology Urinary Retention / epidemiology, etiology*, prevention & control, surgery |
| Chemical | |
Reg. No./Substance:
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0/Azasteroids; 0/Enzyme Inhibitors; 0/dutasteride; 98319-26-7/Finasteride; EC 1.3.99.5/Testosterone 5-alpha-Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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