Document Detail

During neonatal mechanical ventilatory support, the delivered nitric oxide concentration is affected by the ventilatory setting.
MedLine Citation:
PMID:  10834720     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess whether the delivered nitric oxide (NO) concentration is affected by a change in the ventilatory setting during neonatal mechanical ventilatory support. DESIGN: Prospective, experimental study. SETTING: Laboratory at Nagoya City University Medical School. INTERVENTIONS: This study was performed by using a pressure-limited, time-cycled, ventilatory support with a neonatal circuit and a 50-mL silicone test lung. NO in N2 gas was administrated into the inspiratory limb at a distance of 4 cm, 80 cm, or 160 cm from the Y piece connected to the adapter of an endotracheal tube. The NO concentration was measured every 0.5 sec by a chemiluminescence analyzer at the Y piece. MEASUREMENT AND MAIN RESULTS: NO concentrations were compared with each of the ventilatory settings of peak inspiratory pressure (PIP) (10-30 cm H2O), positive end-expiratory pressure (0-10 cm H2O), ventilatory flow (10, 20, 30 L/min), and ventilatory rate (30, 40, 50, 60, 70 breaths/min), respectively. The NO concentration was significantly lower when NO was added at 4 cm than at 80 cm or 160 cm from Y piece at the same ventilatory setting of PIP, positive end-expiratory pressure and ventilatory flow, respectively, (p < .01). Although the NO concentration was increased as the settled PIP level was increased (p < .01 or p < .05), it was not changed when the settled positive end-expiratory pressure level was increased. A decrease was seen in the NO concentration as the settled ventilatory flow was increased (p < .01). Lastly, the NO concentration fluctuated greatly in association with the settled ventilatory rate. CONCLUSION: The NO concentration delivered to patients is influenced by the ventilatory setting during neonatal mechanical ventilatory support.
N Yamaguchi; H Togari; S Suzuki
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  28     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1607-11     Citation Subset:  AIM; IM    
Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan.
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MeSH Terms
Infant, Newborn
Intubation, Intratracheal
Lung Volume Measurements
Nitric Oxide / administration & dosage,  physiology*
Persistent Fetal Circulation Syndrome / physiopathology,  therapy
Prospective Studies
Respiration, Artificial*
Respiratory Distress Syndrome, Newborn / physiopathology*,  therapy
Reg. No./Substance:
10102-43-9/Nitric Oxide

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