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Duration of vancomycin treatment for coagulase-negative Staphylococcus sepsis in very-low-birth-weight infants.
MedLine Citation:
PMID:  23210694     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: Vancomycin is widely used to treat late-onset coagulase-negative Staphylococcus (CoNS) sepsis in very-low-birth-weight (VLBW) infants. Although vancomycin is associated with a risk of toxicity and bacterial resistance, the appropriate duration of use has not been established. This study sought to investigate the association between the duration of vancomycin therapy and clinical outcome in VLBW infants with CoNS sepsis. METHODS: The files of all VLBW infants treated for CoNS sepsis at a tertiary pediatric medical center in 1995-2003 were reviewed for clinical data, laboratory variables, and outcome. Only patients with 2 positive diagnostic blood cultures were included. The findings were analyzed by duration of vancomycin treatment after the last positive blood culture. RESULTS: The study cohort included 126 infants: 48 treated for 5 days, 32 for 6-7 days, 31 for 8-10 days, and 15 for >10 days. There were no differences among the groups in perinatal characteristics, central catheter dwell time, laboratory data including hematologic, renal, and liver function tests, or rate of complications of prematurity. Five infants were diagnosed with infective endocarditis or aortic thrombus and were treated for >10 days. CoNS sepsis recurred in 2 infants (1.6%). No toxicity of vancomycin treatment was observed.
Authors:
Nehama Linder; Daniel Lubin; Adriana Hernandez; Limor Amit; Shai Ashkenazi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  -     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
Affiliation:
Department of Neonatology, Rabin Medical Center, Petach Tikva; Neonatal Intensive Care Unit, Schneider Children's Medical Center of Israel, Petach Tikva; Sackler School of Medicine, Tel Aviv University, Tel Aviv, lsrael.
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