| Duration of labor and risk of cerebral white-matter damage in very preterm infants who are delivered with intrauterine infection. | |
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MedLine Citation:
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PMID: 16157089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to assess whether the duration of labor has any effect on the occurrence of cerebral white-matter damage in very preterm infants who are delivered in the presence of intrauterine infection. STUDY DESIGN: From a cohort of infants who were born spontaneously at <32 weeks of gestation for whom placental information was available and who survived 7 days from birth, 126 infants had clinical, laboratory, or histologic evidence of intrauterine infection. Among them, variables were compared between those infants with white-matter damage (defined as intraventricular hemorrhage grade 3 plus, periventricular leukomalacia, or ventriculomegaly not associated with hydrocephaly [n = 13]) and those infants without it (n = 113). Comparisons were made with t test, chi-squared test, and survival analysis; a probability value of <.05 was considered significant. RESULTS: There were no differences between the 2 groups in gestational age at delivery and rates of labor or cesarean delivery. Duration of active labor (66 +/- 45 minutes vs 88 +/- 75 minutes; P =.49) and of clinical chorioamnionitis (310 +/- 186 minutes vs 529 +/- 544 minutes; P =.44) were similar in cases with and without neonatal white-matter damage. CONCLUSION: In 126 infants who were born at <32 weeks of gestation with intrauterine infection, we found no correlation between the duration of labor or clinical chorioamnionitis and neonatal white-matter damage. |
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Authors:
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Anna Locatelli; Patrizia Vergani; Alessandro Ghidini; Francesca Assi; Claudia Bonardi; John C Pezzullo; Giuseppe Paterlini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 193 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-13 Completed Date: 2005-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 928-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy. anna.locatelli@unimib.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorioamnionitis / epidemiology* Female Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / epidemiology* Labor, Obstetric* Leukomalacia, Periventricular / epidemiology* Male Pregnancy Risk Factors Time Factors |
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