Document Detail

Duration of labor and risk of cerebral white-matter damage in very preterm infants who are delivered with intrauterine infection.
MedLine Citation:
PMID:  16157089     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to assess whether the duration of labor has any effect on the occurrence of cerebral white-matter damage in very preterm infants who are delivered in the presence of intrauterine infection. STUDY DESIGN: From a cohort of infants who were born spontaneously at <32 weeks of gestation for whom placental information was available and who survived 7 days from birth, 126 infants had clinical, laboratory, or histologic evidence of intrauterine infection. Among them, variables were compared between those infants with white-matter damage (defined as intraventricular hemorrhage grade 3 plus, periventricular leukomalacia, or ventriculomegaly not associated with hydrocephaly [n = 13]) and those infants without it (n = 113). Comparisons were made with t test, chi-squared test, and survival analysis; a probability value of <.05 was considered significant. RESULTS: There were no differences between the 2 groups in gestational age at delivery and rates of labor or cesarean delivery. Duration of active labor (66 +/- 45 minutes vs 88 +/- 75 minutes; P =.49) and of clinical chorioamnionitis (310 +/- 186 minutes vs 529 +/- 544 minutes; P =.44) were similar in cases with and without neonatal white-matter damage. CONCLUSION: In 126 infants who were born at <32 weeks of gestation with intrauterine infection, we found no correlation between the duration of labor or clinical chorioamnionitis and neonatal white-matter damage.
Anna Locatelli; Patrizia Vergani; Alessandro Ghidini; Francesca Assi; Claudia Bonardi; John C Pezzullo; Giuseppe Paterlini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  193     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  928-32     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy.
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MeSH Terms
Chorioamnionitis / epidemiology*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology*
Labor, Obstetric*
Leukomalacia, Periventricular / epidemiology*
Risk Factors
Time Factors

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