Document Detail

Duration of ischaemic preconditioning and importance of size of area at risk in pigs.
MedLine Citation:
PMID:  10403754     Owner:  NLM     Status:  MEDLINE    
An explanation of the preconditioning phenomenon must account for the biology of the phenomenon. Here we provide a more thorough characterization of ischaemic preconditioning (IPC), examining temporal characteristics and the importance of the size of area at risk. IPC was induced by two 10-min LAD occlusions separated by 30 min reperfusion in pentobarbital anaesthetized open-chest pigs. The last brief occlusion was followed by either 30 min, 2 h or 4 h of reperfusion. The degree of protection was evaluated by measuring infarct size after either 45 or 60 min LAD occlusion followed by 2 h of reperfusion. To examine the importance of the size of area at risk, the occlusion site on LAD was varied between pigs. IPC followed by 30 min and 2 h of reperfusion reduced infarct size from 58+/-2% of area at risk to 15+/-4% (P<0.05) and 15+/-6% (P<0.05), respectively, by 45 min of LAD occlusion. After 4 h of reperfusion the infarct size-limiting effect of IPC was still prominent when a test ischaemic period of 45 min was used (47+/-5%vs 13+/-1%P<0.05). IPC was paralleled by an increased incidence of ventricular fibrillation during the early phase of the prolonged LAD occlusion after 30 min, 2 h and 4 h of reperfusion. Although no correlation was found between infarct size (as a percentage of area at risk) and area at risk (as a percentage of ventricular weight) in control pigs, a positive correlation was found between these variables in preconditioned pigs. We conclude that the infarct size-limiting effect of IPC lasts at least 4 h and that it is paralleled by profibrillatory effects in open-chest pigs. Furthermore, the infarct size-limiting effect of IPC depends on the size of area at risk, being most pronounced when area at risk is small.
F Grund; K Gjesdal; K A Kirkeboen; A Ilebekk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  31     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1369-80     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Institute for Experimental Medical Research, University of Oslo, Oslo, Norway.
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MeSH Terms
Ischemic Preconditioning, Myocardial*
Myocardial Infarction / physiopathology*
Risk Factors
Time Factors
Ventricular Fibrillation / physiopathology

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