Document Detail

Duration of hyperventilation and outcome in infants with persistent pulmonary hypertension.
MedLine Citation:
PMID:  2451803     Owner:  NLM     Status:  MEDLINE    
Twenty-one infants with the diagnosis of persistent pulmonary hypertension had serial assessments of growth and neurologic development through 12 months of corrected age. Seven infants (30%) had one or more adverse physical outcomes during the first year of life. Four infants (19%) had severe neurologic impairment; seven babies had mild to moderate delay, and 11 babies were found to have no abnormality. Adverse outcome was related to significantly to the duration of hyperventilation, such that the infants without and with abnormalities spent 60 +/- 53 hours and 124 +/- 52 hours hyperventilated, respectively (P less than .01). Our results show that the need for prolonged hyperventilation in infants with persistent pulmonary hypertension is associated with poorer neurodevelopmental outcome.
E M Bifano; A Pfannenstiel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  81     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-05-26     Completed Date:  1988-05-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  657-61     Citation Subset:  AIM; IM    
Department of Pediatrics, State University of New York-Health Science Center, Syracuse 13210.
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MeSH Terms
Cognition / physiology
Developmental Disabilities / etiology*
Infant, Newborn
Neuromuscular Diseases / etiology
Persistent Fetal Circulation Syndrome / complications*
Psychomotor Performance / physiology
Respiration, Artificial / adverse effects*
Time Factors

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