Document Detail

Duration but not intensity of alcohol and tobacco exposure predicts p16INK4A homozygous deletion in head and neck squamous cell carcinoma.
MedLine Citation:
PMID:  16618779     Owner:  NLM     Status:  MEDLINE    
In tobacco-associated solid tumors, evidence suggests that the pattern of carcinogen exposure is related to the nature of somatic gene inactivation within crucial pathways, including the retinoblastoma (Rb) pathway. One somatic event in this pathway, homozygous deletion of the p16INK4A gene, is commonly observed in head and neck squamous cell carcinoma (HNSCC). Alcohol and tobacco are both well-established risk factors for HNSCC but there has been little characterization of the relationship of exposure to these carcinogens and inactivation of the p16INK4A gene. Hypothesizing that p16INK4A homozygous deletion is associated with tobacco and alcohol exposure, we investigated 330 consecutive HNSCC tumors. The odds ratio (OR) for p16INK4A homozygous deletion among alcohol consumers in the upper tertile (>43 years used) was 5.2 [95% confidence interval (95% CI), 2.1-12.8] as compared with those with < or = 43 years of alcohol consumption. Intensity of alcohol exposure, measured as average alcoholic drinks per week, was not associated with gene deletion. When we examined the distribution of duration of tobacco use, the OR for p16(INK4A) homozygous deletion was 1.3 (95% CI, 0.5-3.0) and 1.9 (95% CI, 0.9-4.0) for 29 to 39 years and >39 years of tobacco smoking, respectively, as compared with those that smoked < or = 28 years. As in the case of alcohol use, intensity of tobacco exposure (measured as packs per day) was not associated with gene deletion. Hence, the duration of alcohol use and duration of smoking, but not intensity of either, significantly predicted p16(INK4A) homozygous deletion in HNSCC.
Kim S Kraunz; Michael D McClean; Heather H Nelson; Edward Peters; Henry Calderon; Karl T Kelsey
Related Documents :
21254749 - Low self-esteem in women with eating disorders and alcohol abuse as a psycho-social fac...
12674829 - The co-occurrence of tobacco & alcohol in general population of metropolis delhi.
12077609 - Tobacco use in tunisia: behaviour and awareness.
10334639 - Tobacco and alcohol use and oral cancer in puerto rico.
14768739 - Environmental tobacco smoke and the risk of pancreatic cancer: findings from a canadian...
18507969 - Tobacco and aboriginal people in nsw.
10784519 - Does location of vertebral deformity within the spine influence back pain and disabilit...
12118179 - Osteoporosis in men: pathophysiology, evaluation, and therapy.
2244629 - Occupation and pancreatic cancer risk in louisiana.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cancer research     Volume:  66     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2006-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4512-5     Citation Subset:  IM    
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alcohol Drinking / adverse effects*,  genetics
Case-Control Studies
Cyclin-Dependent Kinase Inhibitor p16 / genetics*
Gene Deletion
Head and Neck Neoplasms / epidemiology,  etiology*,  genetics*
Middle Aged
Smoking / adverse effects*,  genetics
Grant Support
Reg. No./Substance:
0/Cyclin-Dependent Kinase Inhibitor p16

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model.
Next Document:  Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen...