Document Detail

Duration of asthma and lung function in life-long nonsmoking adults.
MedLine Citation:
PMID:  17694695     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The airways of adult or elderly asthmatics are likely candidates for airway remodeling, resulting in persistent airflow obstruction. This population can provide a good model for cross-sectional evaluation of the effect of asthma duration on airflow.
METHODS: We evaluated postbronchodilator airflow and lung volumes at baseline and after a short course of oral prednisone in a group of 42 never-smokers with persistent mild or moderate asthma aged 55 years or older. Patients were grouped as having short duration asthma (SDA, <14 years) or long duration asthma (LDA, > or =14 years) according to the median duration of the disease (14 years) of the sample.
RESULTS: There were no significant differences in patient characteristics or asthma severity indices between the groups. After a short course of prednisone, forced expiratory volume in 1 second (FEV1) and the ratio of FEV to forced vital capacity (FVC) were significantly higher for the SDA group. Only 3 patients presented persistent airflow limitation (FEV1/FVC% < 75%). An inverse correlation was demonstrated between duration of asthma and postbronchodilator FEV1 (% predicted) (r = -0.43, P = .01) and FEV1/FVC% (r = -0.50, P = .003).
CONCLUSION: Our data show a close relationship between duration of disease and loss of lung function, supporting the concept of asthma as a slow, progressive disease at least among those patients with a mild-to-moderate severity. Permanent airflow obstruction in mild or moderate asthma is unusual, but can occur in a small number suffering from the disease for years.
J M Olaguibel Rivera; M J Alvarez-Puebla; M Puy Uribe San Martín; M L Tallens Armand
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigational allergology & clinical immunology     Volume:  17     ISSN:  1018-9068     ISO Abbreviation:  J Investig Allergol Clin Immunol     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-14     Completed Date:  2007-09-04     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  9107858     Medline TA:  J Investig Allergol Clin Immunol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  236-41     Citation Subset:  IM    
Allergology Section, Lung Function Laboratory, Hospital Virgen del Camino, Pamplona, Spain.
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MeSH Terms
Asthma / physiopathology*
Cross-Sectional Studies
Disease Progression
Forced Expiratory Volume*
Middle Aged
Pulmonary Disease, Chronic Obstructive / physiopathology*
Time Factors
Vital Capacity*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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