Document Detail

Duration of antimicrobial prophylaxis for group B streptococcus in patients with preterm premature rupture of membranes who are not in labor.
MedLine Citation:
PMID:  17904972     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the duration of the time that is needed to eradicate group B Streptococcus (GBS) in pregnant women with preterm premature rupture of membranes (PPROM). STUDY DESIGN: A retrospective cohort study was performed of pregnant women with PPROM from January 1, 2000, through December 31, 2005. Vaginal/rectal cultures were performed on admission and repeated daily. Patients received antibiotics until cultures were negative for 3 consecutive days. RESULTS: Two hundred fourteen women were identified with PPROM; 169 of the women met the inclusion criteria. Thirty-three patients were GBS positive on admission and had negative cultures by day 3. Neonatal sepsis occurred in 19 neonates (11.2%); 3 neonates (16%) were from mothers who tested positive for GBS on admission, and 16 neonates (84%) were from mothers who tested negative on admission. There were no cases of neonatal sepsis because of GBS. CONCLUSION: A 3-day regimen of antibiotic prophylaxis appears to be adequate to eradicate GBS from the genital tract of patients with PPROM.
Jesus R Alvarez; Shauna F Williams; Vijaya L Ganesh; Joseph J Apuzzio
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  197     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2007-11-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  390.e1-4     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology and Women's Health, UMDNJ-New Jersey Medical School, Newark, NJ 07101-1709, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis / methods
Clindamycin / therapeutic use
Cohort Studies
Fetal Membranes, Premature Rupture / drug therapy,  microbiology*
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control
New Jersey
Penicillins / therapeutic use
Pregnancy Complications, Infectious / drug therapy*,  microbiology
Retrospective Studies
Streptococcal Infections / drug therapy*,  microbiology
Streptococcus agalactiae / isolation & purification*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Penicillins; 18323-44-9/Clindamycin
Comment In:
Am J Obstet Gynecol. 2008 May;198(5):609-10; author reply 610   [PMID:  18359470 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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