Document Detail

Duration of antibacterial effectiveness of gentamicin ear drops in external otitis.
MedLine Citation:
PMID:  11144828     Owner:  NLM     Status:  MEDLINE    
The recommendation of Anderson and Steele, for the use of ear drops four times a day, has not been changed since 1948. In order to re-evaluate the frequency of using ear drops, we examined the duration of the effectiveness of the antibacterial activity of gentamicin ear drops in external otitis. Seventeen patients (25 ears) with external otitis were studied. We took 18 samples from each ear at 0, 1, 2, 3, 6, 8, 10, 12 and 14 hours and measured the concentration of gentamicin on the wick and in the ear canal. We found that the concentration of gentamicin began to decrease only after 12 hours and a more significant decrease was detected after 14 hours of treatment. We have shown that the antibiotic used on the wick is effective for 12 hours. In conclusion, we recommend using ear drops twice a day on a wick as routine therapy for external otitis.
Y Rakover; A Smuskovitz; R Colodner; Y Keness; G Rosen
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  114     ISSN:  0022-2151     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-28     Completed Date:  2001-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  827-9     Citation Subset:  AIM; IM    
Department of Otorhinolaryngology, Ha'Emek Medical Center, Afula, Israel.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*,  pharmacokinetics,  therapeutic use
Drug Administration Schedule
Drug Delivery Systems
Ear Canal / metabolism
Gentamicins / administration & dosage*,  pharmacokinetics,  therapeutic use
Otitis Externa / drug therapy*,  metabolism
Time Factors
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins

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