| Duration of anti-tubercular treatment in tuberculous meningitis: Challenges and opportunity. | |
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MedLine Citation:
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PMID: 21045495 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: The duration of anti-tuberculous therapy in tuberculous meningitis is controversial. There is variation in recommendations by different societies and expert groups on this issue. Objective: To determine the strength of evidence for short-term therapy in tuberculous meningitis through review of literature and critical appraisal. Materials and Methods: Cochrane CENTRAL (Issue 4, 2010), TRIP database, and PubMed (from 1966 to present) were searched for relevant papers with keywords 'meningeal tuberculosis' and tuberculous meningitis' combined with 'chemotherapy'. A critical appraisal of a systematic review was done using standard criteria. Results: A total of 10 relevant papers were identified. All papers were included in a systematic review. The systematic review did not specify study design of studies to be included, had only case series but no randomised controlled trial, and unclear definition of endpoints. Conclusions: The evidence base for short-term therapy for tuberculous meningitis is weak. There is a need to conduct a randomised controlled trial with non-inferiority hypothesis of adequate sample size with well-defined end points and adequate follow-up. This is a challenge as well as opportunity for Indian neurologists. |
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Authors:
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Kameshwar Prasad; Jitendra Kumar Sahu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurology India Volume: 58 ISSN: 0028-3886 ISO Abbreviation: Neurol India Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042005 Medline TA: Neurol India Country: India |
Other Details:
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Languages: eng Pagination: 723-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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