Document Detail

Duration of allergic susceptibility in maternal transmission of asthma risk.
MedLine Citation:
PMID:  17631005     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Asthma has its origins in early-life. Maternal, not paternal asthma is an important risk factor, but the mechanisms and the duration of the maternal effect are unknown. METHOD OF STUDY: Offspring of asthmatic and normal mice were sensitized with ovalbumin (OVA) at 1, 3, 6 and 10 weeks of age, challenged with aerosolized OVA 2 weeks later and tested for airway hyperresponsiveness (AHR) and allergic airway inflammation (AI). RESULTS: Offspring of asthmatic, but not normal, mothers showed AHR and AI after OVA sensitization at week 1. Similarly increased susceptibility to OVA was observed when sensitized at 3 or 6 weeks, although the magnitude diminished. Offspring sensitized at 10 and challenged at 12 weeks showed some AI but no AHR. CONCLUSION: In offspring from asthmatic mothers increased allergic susceptibility persisted through the young adulthood, albeit with gradual decline, which suggests a long-lived but reversible skewing of the developing immune system.
Alexey V Fedulov; Adriana S Leme; Lester Kobzik
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  58     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-09-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  120-8     Citation Subset:  IM    
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
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MeSH Terms
Animals, Newborn
Asthma / genetics*
Disease Models, Animal
Genetic Predisposition to Disease*
Infectious Disease Transmission, Vertical*
Mice, Inbred BALB C
Risk Factors
Grant Support

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