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Duration Until Nighttime Blood Pressure Fall Indicates Excess Sodium Retention.
MedLine Citation:
PMID:  23130664     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Impaired renal sodium excretion causes sodium retention, which prevents the nocturnal dip in blood pressure (BP); thus, high BP persists until excess sodium is excreted. The authors defined "dipping time" (DT) as the duration until the nocturnal BP falls below 90% of the daytime average. Diuretic (e.g., hydrochlorothiazide [HCTZ]) and angiotensin receptor blocker (ARB) are able to eliminate sodium retention and restore the non-dipper BP rhythm. Reanalysis of two previous studies demonstrate that HCTZ and ARB shortened the DT. Shortening DT correlated directly with the increase in daytime urinary sodium excretion (Study 2). DT can be used as a preliminary indicator of sodium retention. (Author correspondence: m-fukuda@med.nagoya-cu.ac.jp ).
Authors:
Michio Fukuda; Takashi Uzu; Genjiro Kimura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-6
Journal Detail:
Title:  Chronobiology international     Volume:  -     ISSN:  1525-6073     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardio-Renal Medicine and Hypertension , Nagoya City University Graduate School of Medical Sciences , Nagoya , Japan.
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