| Duration of L-dopa and dopamine agonist monotherapy in Parkinson's disease. | |
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MedLine Citation:
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PMID: 23002158 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The expected duration of initial antiparkinson monotherapy before the need for supplementation is not clearly defined for routine practice. The aim of this study was to define the length of l-dopa (L-3, 4-dihydrophenylalanine) and dopamine agonist monotherapy. The duration of monotherapy and discontinuation rates were investigated in a natural observational setting by plotting Kaplan-Meier survival curves. Out of 345 patients, 180 (52.2%) received l-dopa and 165 (47.8%) received a dopamine agonist as initial monotherapy. Half of the patients starting l-dopa received supplementary therapy with- in 3.6 years (95% confidence interval, 3.2-4.6), significantly longer than for dopamine agonist monotherapy (half required a second agent at 2.3 years [2.0-2.9]; P = 0.00017). Discontinuation of l-dopa therapy was 1%. Dopamine agonists were stopped (due to side-effects like impulse control disorders [6%], somnolence [4%] and light-headedness [3%]) in 20% over four years. The duration and tolerability of l-dopa and dopamine agonists as initial Parkinson's disease monotherapy are defined in this study; this may form part of the information exchange with patients. |
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Authors:
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T Nissen; E J Newman; K A Grosset; M Daghem; G Pal; M Stewart; P Odin; G J Macphee; D G Grosset |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-21 |
Journal Detail:
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Title: Scottish medical journal Volume: - ISSN: 0036-9330 ISO Abbreviation: Scott Med J Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983335R Medline TA: Scott Med J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neurology, Klinikum Bremerhaven, Bremerhaven, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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