Document Detail

Dural ectasia is a common feature of the Marfan syndrome.
MedLine Citation:
PMID:  3189335     Owner:  NLM     Status:  MEDLINE    
Widening of the lumbosacral spinal canal was found in 63% of 57 patients with the Marfan syndrome and in none of 57 age- and sex-matched non-Marfan control patients, who underwent CT scanning for routine clinical indications. The bony abnormalities in mild cases consisted of thinning of the pedicles and taminae and erosion of the neural foraminae and were generally limited to L5 and S1. More severe changes were present in 13 patients, two of whom had associated neurologic signs, and included meningoceles or near total erosion of a pedicle. Presence and severity of vertebral abnormalities were associated with neither any other clinical feature nor overall phenotypic severity. Dural ectasia can be added to the list of pleiotropic manifestations of the Marfan syndrome.
R E Pyeritz; E K Fishman; B A Bernhardt; S S Siegelman
Related Documents :
2334215 - Contractural arachnodactyly with mitral regurgitation and iridodonesis.
6607995 - Aortic insufficiency in reiter's syndrome of juvenile onset.
18084245 - Aberrant fibrillin-1 expression in early emphysematous human lung: a proposed predispos...
10617925 - Iridocorneal adhesions in patients with the marfan syndrome.
9949225 - Seckel-like syndrome in three siblings.
19774195 - Prenatal diagnosis of fetal syndromes.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of human genetics     Volume:  43     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-01     Completed Date:  1988-12-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  726-32     Citation Subset:  IM    
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Dilatation, Pathologic / radiography
Marfan Syndrome / genetics*,  pathology,  radiography
Spinal Canal / pathology,  radiography*
Tomography, X-Ray Computed
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Population amalgamation and genetic variation: observations on artificially agglomerated tribal popu...
Next Document:  Chromosome elimination in micronuclei: a common cause of hypoploidy.