| Durable hypogammaglobulinemia associated with thymoma (Good syndrome). | |
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MedLine Citation:
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PMID: 19797831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Good syndrome, characterized by hypogammaglobulinemia and acquired immunodeficiency, is a rare condition associated with thymoma. A 67-year-old woman, who 4 months previously had a thymoma resected, presented with generalized hypogammaglobulinemia with a severely decreased B cell population as demonstrated by flow cytometry. She was diagnosed as having bacterial mediastinitis associated with Good syndrome. For the subsequent 6 years, she suffered from repeated serious bacterial infections. As this paraneoplastic syndrome is not resolved by tumor removal, careful management with intensive infection-control using antibiotics and intravenous immunoglobulins is required for the long term. Serum immunoglobulin levels should be evaluated for patients with thymoma and suspected vulnerability to infection. |
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Authors:
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Atsushi Kitamura; Yuichi Takiguchi; Naobumi Tochigi; Shun-ichi Watanabe; Seiichirou Sakao; Katsushi Kurosu; Nobuhiro Tanabe; Koichiro Tatsumi |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-10-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 48 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-02 Completed Date: 2009-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1749-52 Citation Subset: IM |
Affiliation:
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Department of Respirology, Graduate School of Medicine, Chiba University, Chiba. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Agammaglobulinemia
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complications*,
immunology Aged B-Lymphocytes / immunology Female Humans Immunologic Deficiency Syndromes / complications, immunology Lymphopenia / complications, immunology Paraneoplastic Syndromes / complications, immunology Syndrome Thymoma / complications*, diagnosis, immunology Thymus Neoplasms / complications*, diagnosis, immunology Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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