| Durability of Rifaximin Response in Hepatic Encephalopathy. | |
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MedLine Citation:
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PMID: 22011586 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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GOALS:: To evaluate the durability of the response to rifaximin for treatment of hepatic encephalopathy (HE). BACKGROUND:: The nonsystemic antibiotic rifaximin has been approved for maintenance of HE remission, and several studies have indicated the efficacy of rifaximin for acute HE; however, the duration of therapeutic response for >6 months remains unknown. STUDY:: Medical records of patients with cirrhosis who received rifaximin maintenance therapy for HE between January 2004 and May 2009 were reviewed. Model for end-stage liver disease (MELD) scores were obtained every 3 months during therapy. RESULTS:: Of 203 patients with HE (Conn score ≥2), 149 received rifaximin monotherapy (400 to 1600 mg/d) and 54 received rifaximin (600 to 1200 mg/d) and lactulose (90 mL/d) dual therapy. Maintenance of HE remission for 1 year occurred in 81% and 67% of patients who received rifaximin monotherapy and rifaximin and lactulose dual therapy, respectively. Patient populations with a baseline mean MELD score ≤20 had few overt HE events, suggesting increased response to rifaximin in these patients. CONCLUSIONS:: Rifaximin is effective for the management of HE in patients with cirrhosis, particularly in populations with MELD scores ≤20. Additional studies are needed to investigate the potential association between MELD scores and the efficacy of HE treatments. |
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Authors:
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Guy W Neff; Michael Jones; Taylor Broda; Mark Jonas; Ravinuthala Ravi; David Novick; Tiffany E Kaiser; Nyingi Kemmer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-18 |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: - ISSN: 1539-2031 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Tampa General Medical Group, Tampa, FL †Tri-State Gastroenterology Associates ‡University of Indianapolis, Indianapolis, IN §Greater Cincinnati Gastroenterology Associates, Cincinnati ∥Digestive Specialists, Inc, Dayton, OH. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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