| Duodenogastric reflux in humans: its relationship to fasting antroduodenal motility and gastric, pancreatic, and biliary secretion. | |
| | |
MedLine Citation:
|
PMID: 7262517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Duodenogastric reflux may have pathophysiologic importance, but its mechanism is poorly understood. We propose that duodenogastric reflux and periodic changes in motor and secretory activity of the upper gut during fasting may be related. Therefore we determined the relationships between duodenogastric reflux and interdigestive motor-secretory cycles in a group of 6 healthy individuals, on each of whom we performed three 7-h studies in random order on separate days. In all studies gastric intubation and antral pressure recordings were performed. However, in design 1 we used a slow duodenal perfusion rate of [14C]PEG in saline (0.25 ml/min) while in design 3 we used a fast perfusion rate (3.0 ml/min). Duodenal pressures were also recorded during these designs. In design 2 no transpyloric tubes were present. Our study shows that, in humans, fasting duodenogastric reflux of bile and pancreatic juice is cyclic and closely related to the interdigestive migrating motor complex. Reflux is highest during late phase II (when secretory activity is also on the rise) and lowest after phase III. One of the important functions of the migrating motor complex in humans may be to clear the stomach of refluxed duodenal secretions. |
| | |
Authors:
|
F B Keane; E P Dimagno; J R Malagelada |
Related Documents
:
|
3221107 - Pressure of papillary sphincter zone and pancreatic main duct in patients with alcoholi... 9793467 - Effect of some gastrointestinal hormones on antral, small intestinal and caecal myoelec... 16504467 - Behavior of the cricopharyngeal segment during esophageal phonation in laryngectomized ... 3815457 - Effects of pinaverium bromide on oddi's sphincter. 22559577 - High-pressure cell for neutron reflectometry of supercritical and subcritical fluids at... 7263397 - Regular fetal breathing induced by pilocarpine infusion in the near-term fetal lamb. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Gastroenterology Volume: 81 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1981 Oct |
Date Detail:
|
Created Date: 1981-10-25 Completed Date: 1981-10-25 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 726-31 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Bile / secretion* Duodenum / physiology*, secretion Fasting Gastric Acid / secretion* Gastrointestinal Motility* Humans Middle Aged Pancreas / secretion* Perfusion Stomach / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
AM 26428/AM/NIADDK NIH HHS; CA 25064/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Indomethacin produces gastric antral ulcers in the refed rat.
Next Document: Patterns of spike burst spread and flow in the canine small intestine.