Document Detail


Duodenal disappearance rate of acid during inhibition of mucosal bicarbonate secretion.
MedLine Citation:
PMID:  2083798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to investigate the relation between duodenal mucosal and pancreaticobiliary bicarbonate secretion, we have studied the effect of inhibition of mucosal bicarbonate secretion by indomethacin on the disappearance rate of acid and the concomitant plasma secretin concentrations. 10 healthy subjects were studied twice, with and without indomethacin pretreatment. By means of a double-lumen tube the duodenum was perfused with increasing amounts of acid (0, 3.0, 6.0 and 9.5 mmol/h) and the disappearance rate of acid, pH of duodenal aspirate and plasma secretin were measured. In both experiments nearly all acid, even at the highest acid load, disappeared (pH greater than 6). Inhibition of the duodenal mucosal bicarbonate secretion did not decrease the acid-neutralizing capacity of the human duodenum. In fact, the disappearance rate of acid at the highest acid load was a little greater when mucosal bicarbonate secretion had been inhibited than when not (10.3 +/- 0.5 vs. 9.2 +/- 0.2 mmol/h). The pancreaticobiliary secretion of bicarbonate, as judged by plasma secretin concentrations, increased, however, earlier when mucosal bicarbonate secretion had been inhibited than when not (3.7 vs. 3.0 pmol/l at an acid load of 6.0 mmol/h). This indicates that bicarbonate from the duodenal mucosa normally plays a role in the in lumen neutralization of acid in the human duodenum.
Authors:
M A Ainsworth; J Kjeldsen; O Olsen; P Christensen; O B Schaffalitzky de Muckadell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestion     Volume:  47     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-16     Completed Date:  1991-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  121-9     Citation Subset:  IM    
Affiliation:
Department of Medical Gastroenterology, Odense University Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bicarbonates / antagonists & inhibitors*,  metabolism
Duodenum / metabolism*
Female
Gastric Acid / metabolism*
Humans
Hydrogen-Ion Concentration
Indomethacin / pharmacology*
Intestinal Mucosa / metabolism*
Liver / metabolism
Male
Pancreas / metabolism
Secretin / blood
Chemical
Reg. No./Substance:
0/Bicarbonates; 1393-25-5/Secretin; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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