Document Detail

Dumping syndrome: establishing criteria for diagnosis and identifying new etiologies.
MedLine Citation:
PMID:  19714467     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate the current incidence and identify the current etiologies of rapid gastric emptying (dumping syndrome) in patients with a spectrum of gastrointestinal symptoms, including nausea, vomiting, abdominal pain, or diarrhea. METHODS: The results for a 4-h radionuclide gastric emptying test (GET) using a standardized scintigraphic technique were reviewed in 545 patients to see which patients met criteria for rapid gastric emptying, defined as >50% emptying of isotope-labeled solid meal at 1 h. RESULTS: Forty-eight of 545 (8.8%) patients (28 females, mean age 46 +/- 2 years, range 32-58 years) had rapid GET. Seventeen of 59 (35%) met Rome III diagnostic criteria for cyclic vomiting syndrome (CVS). Twelve of these 59 (25%) patients were regarded as non-ulcer dyspepsia and six (13%) had dyspepsia in the setting of diabetes mellitus. Five (10.5%) were post-fundoplication surgery, where an accidental vagotomy was confirmed by sham meal challenge; previous gastric bypass surgery for obesity had been performed in three (6%) patients. Five (10.5%) patients with unexplained abdominal pain and diarrhea had the working diagnosis of irritable bowel syndrome. CONCLUSIONS: Rapid gastric emptying can be identified in a sizeable subset (9%) of patients with unexplained nausea, vomiting, abdominal pain, and diarrhea when criteria are applied to the standardized scintigraphic gastric emptying meal.
Reza A Hejazi; Harshal Patil; Richard W McCallum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  55     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-30     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  AIM; IM    
Department of Medicine, Division of Gastroenterology, Kansas University Medical Center, Kansas City, KS, USA.
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MeSH Terms
Abdominal Pain / etiology
Diarrhea / etiology
Dumping Syndrome / diagnosis*,  etiology,  physiopathology
Gastric Emptying
Middle Aged
Nausea / etiology
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Sulfur Colloid / diagnostic use
Vomiting / etiology
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Technetium Tc 99m Sulfur Colloid

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