| Duffy locus linkage and HLA antigens in hereditary motor-sensory neuropathy. | |
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MedLine Citation:
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PMID: 1709295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Duffy system, Fya, Fyb, and HLA antigens were studied in 86 members, 39 affected, 47 healthy subjects, of 17 families with HMSN types I, II and III. The incidence of autosomal dominant as well as recessive, or sporadic forms was registered. In the autosomal dominant form of HMSN type I a close linkage was found between the genes coding the disease under study and the determinants Fya and Fyb. Recombination was found in only 9.1% of the cases. A study of HLA antigens revealed a major decrease in antigen B27 in the patients under scrutiny. An identical haplotype of most of the parents was a conspicuous feature in families with the autosomal dominant form of HMSN type I. |
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Authors:
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S Nevsímalová; J Prazák; P Herzog; E Seemanová |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Schweizer Archiv für Neurologie und Psychiatrie (Zurich, Switzerland : 1985) Volume: 142 ISSN: 0258-7661 ISO Abbreviation: Schweiz Arch Neurol Psychiatr Publication Date: 1991 |
Date Detail:
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Created Date: 1991-06-10 Completed Date: 1991-06-10 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8503709 Medline TA: Schweiz Arch Neurol Psychiatr Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 19-29 Citation Subset: IM |
Affiliation:
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Neurological Department, Charles University Medical Faculty, Prague, Czechoslovakia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Chromosome Aberrations / genetics Chromosome Disorders Chromosome Mapping* Duffy Blood-Group System / genetics* Female Gene Frequency / genetics Genes, Dominant / genetics Genes, Recessive / genetics HLA Antigens / genetics* HLA-B27 Antigen / genetics Hereditary Sensory and Motor Neuropathy / genetics* Humans Linkage (Genetics) / genetics* Male Middle Aged Pedigree |
| Chemical | |
Reg. No./Substance:
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0/Duffy Blood-Group System; 0/HLA Antigens; 0/HLA-B27 Antigen |
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