| Ductus arteriosus wave intensity analysis in fetal lambs: midsystolic ductal flow augmentation is due to antegrade pulmonary arterial wave transmission. | |
| | |
MedLine Citation:
|
PMID: 19692659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In midsystole, fetal pulmonary trunk (PT) and arterial (PA) blood flows characteristically fall, despite pulmonary blood pressure increasing, while ductus arteriosus (DA) flow continues to rise to a delayed peak. Wave intensity (WI) analysis indicates that midsystolic fetal PT and PA flow reductions are related to a very large midsystolic PA backward-running compression wave (BCW(ms)), which originates in the pulmonary microvasculature and is partially transmitted into the PT. This study tested the hypothesis that midsystolic augmentation of DA blood flow was related to transmission of the PA BCW(ms) into the DA. DA, PT, and PA WI analysis was performed in eight anesthetized late-gestation fetal sheep instrumented with DA, PT, and left PA micromanometer catheters to measure pressure (P) and transit-time flow probes to obtain blood velocity (U). In a subgroup (n = 5), the main PA was briefly occluded to abolish wave transmission from the lungs. WI was calculated as the product of P and U rates of change. PA and PT WI profiles both contained a prominent BCW(ms), approximately 5-fold larger in the PA (P < 0.005), which increased P but decreased U. By contrast, the DA WI profile demonstrated a large midsystolic forward-running compression wave (FCW(ms)), which increased DA P and U, and occurred 5 ms after PA BCW(ms). Furthermore, both DA FCW(ms) and PT BCW(ms) were abolished by main PA occlusion. These results suggest that the fetal PA BCW(ms) undergoes retrograde transmission into the PT as a BCW(ms), but antegrade transmission into the DA as a FCW(ms) that augments midsystolic DA flow. |
| | |
Authors:
|
Joseph J Smolich; Jonathan P Mynard; Daniel J Penny |
Related Documents
:
|
2696779 - Intrauterine treatment of severe fetal erythroblastosis: intravascular transfusion with... 12853089 - Prolonged reductions in placental blood flow and cerebral oxygen delivery in preterm fe... 20027029 - Effects of magnesium sulfate on preterm fetal cerebral blood flow using doppler analysi... 10725499 - Effect of prolonged asphyxia on skin blood flow in fetal lambs. 8498449 - Effect of rapid intravenous crystalloid infusion on uteroplacental blood flow and place... 7786519 - Haemodynamic responses to an angiotensin ii receptor antagonist (gr 117289) in maternal... 19395089 - Conception season and cerebral asymmetries among american baseball players: implication... 16322729 - Computational design and experimental performance testing of an axial-flow pediatric ve... 6175369 - Effect of converting enzyme inhibition on the renal haemodynamic responses to noradrena... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-19 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 297 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-28 Completed Date: 2009-10-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R1171-9 Citation Subset: IM |
Affiliation:
|
Department of Paediatrics, Heart Research Group, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia. joe.smolich@mcri.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Flow Velocity Blood Pressure Carbon Dioxide / blood Coronary Circulation* Ductus Arteriosus / physiology*, ultrasonography Echocardiography, Doppler Female Fetal Blood / metabolism Gestational Age Hydrogen-Ion Concentration Oxygen / blood Pregnancy Pulmonary Artery / embryology, physiology*, ultrasonography Pulmonary Circulation* Regional Blood Flow Sheep |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Benefits of oat beta-glucan and sucrose feedings on infection and macrophage antiviral resistance fo...
Next Document: Aerobic exercise training improves whole muscle and single myofiber size and function in older women...