Document Detail


Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus.
MedLine Citation:
PMID:  18287969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Premature newborn baboons [125 d (67%) gestation], exposed to a moderate-size patent ductus arteriosus (PDA) [pulmonary-to-systemic blood-flow-ratio (Qp/Qs) = 1.8] for 14 d, have impaired pulmonary function and arrested alveolar development and surface area when compared with age matched fetuses (140 d gestation). Pharmacologic closure of the PDA reduces the detrimental effects of preterm delivery on pulmonary function and surface area. We used preterm baboons (delivered at 125 d gestation and ventilated for 14 d) to study the effects of surgical PDA ligation on pulmonary function and alveolar surface area. After ligation (on day of life 6), ligated animals had lower Qp/Qs ratios [Qp/Qs (ligated, n = 10) = 1.00 +/- 0.04; (nonligated, n = 12) = 2.05 +/- 0.17; mean +/- SD] and higher systemic blood pressures than nonligated control animals. Ventilation and oxygenation indices did not differ between the groups, during either the pre- or postoperative periods. Alveolar surface area measurements were made by digital image analysis and compared with measurements made from fetal lungs at 125 d (n = 6) and 140 d (n = 7) gestation. PDA ligation failed to improve the postnatal arrest in alveolar surface area. In contrast with pharmacologic closure of the PDA, surgical closure failed to improve either pulmonary function or alveolar surface area in baboons with a moderate PDA shunt.
Authors:
Ling Yi Chang; Donald McCurnin; Bradley Yoder; Phillip W Shaul; Ronald I Clyman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  63     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-21     Completed Date:  2008-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Colorado, Denver, Colorado 80204, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Cardiac Surgical Procedures*
Disease Models, Animal
Ductus Arteriosus, Patent / drug therapy,  pathology,  physiopathology,  surgery*
Female
Gestational Age
Ibuprofen / pharmacology,  therapeutic use
Ligation
Lung Compliance
Male
Papio papio
Premature Birth*
Pulmonary Alveoli / drug effects,  embryology,  growth & development*,  pathology,  physiopathology
Pulmonary Circulation
Pulmonary Ventilation
Respiration, Artificial
Respiratory Function Tests
Signal Processing, Computer-Assisted
Time Factors
Grant Support
ID/Acronym/Agency:
HL46691/HL/NHLBI NIH HHS; HL52636/HL/NHLBI NIH HHS; HL56061/HL/NHLBI NIH HHS; HL63397/HL/NHLBI NIH HHS; HL63399/HL/NHLBI NIH HHS; P51RR13986/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
15687-27-1/Ibuprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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