Document Detail

Ductopenia related liver sarcoidosis.
MedLine Citation:
PMID:  22509431     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Sarcoidosis is a systemic granulomatous disease which may involve many organs. In approximately 95% of patients there is liver involvement, with noncaseating hepatic granulomas occurring in 21 to 99% of patients with sarcoidosis. Liver involvement is usually asymptomatic and limited to mild to moderate abnormalities in liver biochemistry. The occurrence of jaundice in sarcoidosis is rare; extensive imaging procedures and the examination of liver biopsies permit a precise diagnostic. Ductopenia associated with sarcoidosis has been reported in less than 20 cases and can lead to biliary cirrhosis and liver- related death. We report here on a case of ductopenia-related sarcoidosis in which primary biliary cirrhosis and extrahepatic cholestasis have been carefully excluded. The patient follow up was 8 years. Although ursodesoxycholic acid appears to improve liver biochemistry it does not preclude the rapid occurrence of extensive fibrosis. A review of the literature of reported cases of ductopenia related to sarcoidosis is provided.
Nourr-Eddine Farouj; Jean-François D Cadranel; Ali Mofredj; Vincent Jouannaud; Maria Lahmiri; Pierre Le Lann; Alain Cazier
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of hepatology     Volume:  3     ISSN:  1948-5182     ISO Abbreviation:  World J Hepatol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2012-04-17     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101532469     Medline TA:  World J Hepatol     Country:  China    
Other Details:
Languages:  eng     Pagination:  170-4     Citation Subset:  -    
Nourr-Eddine Farouj, Ali Mofredj, Intensive Care Department, Centre Hospitalier Laënnec BP 72 60100 Creil, France.
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