Document Detail

Ductal ligation in the very low-birth weight infant: simple anesthesia or extreme art?
MedLine Citation:
PMID:  22489639     Owner:  NLM     Status:  MEDLINE    
Management of the very low-birth weight infant in the neonatal intensive care unit (NICU) is geared to provide optimal outcome not only in term of survival but increasingly with a goal of limitation of long-term neurological and pulmonary morbidities. Careful follow-up studies have demonstrated that relatively small variations in oxygenation and gas exchange, ventilator management, and other management modalities can have long-term consequences. Within this context, there are good data that closure of a clinically significant patent ductus arteriosus has outcome benefit, but little data on the idealized anesthetic to manage such fragile patients. Does the anesthetic management matter? Given the attention to detail within the NICU, it would seem prudent to try to choose techniques that limit changes in hemodynamics, gas exchange, and ventilation within the context of the surgery. Anesthesia for ductal ligation in the very low-birth weight infant may need to be judged by more than simple survival and brings into question the current techniques and monitoring used.
Andrew R Wolf
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-04-10
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  22     ISSN:  1460-9592     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-18     Completed Date:  2012-09-14     Revised Date:  2013-02-14    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  558-63     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Paediatric Anaesthesia and Intensive Care, Bristol Royal Children's Hospital, Bristol, UK.
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MeSH Terms
Anesthesia / methods*
Blood Glucose / metabolism
Carbon Dioxide / physiology
Ductus Arteriosus, Patent / surgery*
Infant, Newborn
Infant, Very Low Birth Weight / physiology*
Intensive Care
Ligation / methods*
Oxygen / pharmacology,  physiology
Oxygen Inhalation Therapy
Pain Management
Spectroscopy, Near-Infrared
Reg. No./Substance:
0/Blood Glucose; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen
Comment In:
Paediatr Anaesth. 2013 Feb;23(2):200-1   [PMID:  23289774 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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