| Ductal invasive mammary carcinoma--clinicopathological prognostic factors related to immunohistochemical expression of hormonal receptors and Her2/neu oncoprotein. | |
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MedLine Citation:
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PMID: 22119825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analyzed 75 cases of invasive ductal mammary carcinoma type NOS and focused on comparative investigation of hormonal receptors (estrogen receptor ER and progesterone receptor PR) and Her2/neu oncoprotein expression, according to which we ranked the cases in molecular classification subtypes, determining certain correlations between them and morphoclinical prognostic factors. 73.4% of cases were ER+ and 26.6% were ER-. PR was present in 62.6% of cases and absent in 37.4%. Phenotype ER+PR+ (58.6%) had the highest incidence, followed by ER-PR- (22.8%) and ER+PR- (14.6%). Phenotype ER-PR+ (4%) registered the lowest incidence. 14.8% of tumors were Her2/neu + score 3+, 4% had equivocal score 2+ and 81.3% were negative Her2/neu scored 0 and 1+. 9.5% of cases Her2/neu positive scored 3+ were ER+PR+ and 88.5% of cases Her2/neu negative scored 0-1 were ER+PR+. In terms of the correlation among the status of ER, PR and Her2/neu, we determined a molecular classification of the cases, obtaining the following incidences: luminal A 70% of cases, basal 14.7% of cases, luminal B 8.3%, the lowest incidence being registered at Her2, 7% of cases. Luminal A and basal subtypes were associated with patients aged over 50 years (82% for luminal A and 90% for basal), whereas luminal B and Her2 subtypes were registered mostly at patients aged under 60-year-old (83% for luminal B and 100% for Her2). Luminal A subtype was characterized by small tumors (92% of cases were T1-T2), well and moderately differentiated tumors (58% of cases were G1-G2). 83.3% of cases in luminal B subtype had tumors with dimensions ranked T2-T3, all cases being moderately and low differentiated. Her2 subtype had T2-T3 tumors in 60% of cases, which were G3 low differentiated in a percent of 80%. The basal subtype mostly had tumors larger than 5 cm (91% of cases were T2-T3), out of which only a case (9%) presented well-differentiated G1. |
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Authors:
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Felicia Recăreanu; Cristiana Simionescu; Claudia Valentina Georgescu; Elena Pirici |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie Volume: 52 ISSN: 1220-0522 ISO Abbreviation: Rom J Morphol Embryol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-11-28 Completed Date: 2012-03-15 Revised Date: 2012-10-12 |
Medline Journal Info:
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Nlm Unique ID: 9112454 Medline TA: Rom J Morphol Embryol Country: Romania |
Other Details:
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Languages: eng Pagination: 1059-64 Citation Subset: IM |
Affiliation:
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University of Medicine and Pharmacy of Craiova, Romania. feliciarecareanu@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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metabolism*,
pathology* Carcinoma, Ductal, Breast / classification, metabolism*, pathology* Cell Differentiation Female Humans Immunohistochemistry Middle Aged Neoplasm Invasiveness Prognosis Receptor, erbB-2 / metabolism* Receptors, Estrogen / metabolism* Receptors, Progesterone / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Estrogen; 0/Receptors, Progesterone; EC 2.7.10.1/ERBB2 protein, human; EC 2.7.10.1/Receptor, erbB-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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