Document Detail

Ductal Closure With Paracetamol: A Surprising New Approach to Patent Ductus Arteriosus Treatment.
MedLine Citation:
PMID:  22065264     Owner:  NLM     Status:  Publisher    
Standard pharmacologic closure of the patent ductus arteriosus currently involves the administration of 1 of 2 cyclooxygenase inhibitors: either indomethacin or ibuprofen. However, both of these drugs can be associated with potentially significant adverse effects. We present here the cases of 5 preterm infants (gestational age: 26-32 weeks; postnatal age: 3-35 days) with large, hemodynamically significant patent ductus arteriosus who had either failed or had contraindications to ibuprofen therapy. Each of these infants was treated with off-label oral paracetamol (15 mg/kg per dose every 6 hours). Ductal closure was achieved within 48 hours in all the treated infants. No toxicity was observed.
Cathy Hammerman; Alona Bin-Nun; Einat Markovitch; Michael S Schimmel; Michael Kaplan; Daniel Fink
Related Documents :
21054514 - Exploring the olfactory environment of premature newborns: a french survey of health ca...
22020324 - Expression of brain-derived neurotrophic factor and trkb receptor in the sudden infant ...
22416594 - Six-month-old infants perceive the hollow-face illusion.
22004614 - Cost-effectiveness of intermittent preventive treatment of malaria in infants (ipti) fo...
19419504 - Cerebral blood flow monitoring using a novel laser doppler flowmeter in asphyxiated inf...
2921184 - The relationship between maternal weight for height and term birth weight in teens and ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-7
Journal Detail:
Title:  Pediatrics     Volume:  -     ISSN:  1098-4275     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of Neonatology and.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antibiotic Prescribing in Ambulatory Pediatrics in the United States.
Next Document:  Parent participation and physician-parent communication during informed consent in child leukemia.