Document Detail


Duct ligation and pancreatic islet blood flow in rats: physiological growth of islets does not affect islet blood perfusion.
MedLine Citation:
PMID:  16061842     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to evaluate islet blood-flow changes during stimulated growth of the islet organ without any associated functional impairment of islet function. DESIGN: A duct ligation encompassing the distal two-thirds of the pancreas was performed in adult, male Sprague-Dawley rats. METHODS: Pancreatic islet blood flow was measured in duct-ligated and sham-operated rats 1, 2 or 4 weeks after surgery. In some animals studied 4 weeks after surgery, islet blood flow was also measured also during hyperglycaemic conditions. RESULTS: A marked atrophy of the exocrine pancreas was seen in all duct-ligated rats. Blood glucose and serum insulin concentrations were normal. An increased islet mass was only seen 4 weeks after surgery. No differences in islet blood perfusion were noted at any time point after duct ligation. In both sham-operated and duct-ligated rats islet blood flow was increased during hyperglycaemia; the response was, however, slightly more pronounced in the duct-ligated part of the gland. CONCLUSIONS: Normal, physiological islet growth does not cause any major changes in the islet blood perfusion or its regulation. This is in contrast to findings during increased functional demands on the islets or during deteriorated islet function, when increased islet blood flow is consistently seen.
Authors:
Leif Jansson; Birgitta Bodin; Orjan Källskog; Arne Andersson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  153     ISSN:  0804-4643     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-02     Completed Date:  2005-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
Affiliation:
Department of Medical Cell Biology, Uppsala University, Sweden. Leif.Jansson@medcellbiol.uu.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrophy
Blood Glucose
Hyperglycemia / physiopathology
Insulin / blood
Islets of Langerhans / blood supply*,  growth & development*,  physiology
Ligation
Male
Pancreas, Exocrine / blood supply,  pathology,  physiology
Pancreatic Ducts
Rats
Rats, Sprague-Dawley
Regional Blood Flow / physiology*
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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