| Duct tape for broken chromosomes. | |
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MedLine Citation:
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PMID: 20141831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A cell undergoing mitosis is presented with a potentially catastrophic situation when a DNA double-strand break creates a chromosome fragment that lacks connection to a centromere. Royou et al. (2010) now reveal that this cellular crisis is averted in fruit fly neuroblasts by thin chromatin tethers that hold on to the ends of the broken chromosomes. |
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Authors:
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Gary J Gorbsky |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Cell Volume: 140 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-09 Completed Date: 2010-02-25 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 178-80 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Cell Cycle & Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA. gjg@omrf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Centromere / metabolism* Chromosomes / metabolism* DNA Breaks, Double-Stranded Drosophila / cytology*, embryology, metabolism* Mitosis |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM050412-17/GM/NIGMS NIH HHS; R01 GM050412-18/GM/NIGMS NIH HHS |
| Comments/Corrections | |
Comment On:
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Cell. 2010 Jan 22;140(2):235-45
[PMID:
20141837
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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