Document Detail

Duchenne muscular dystrophy: negative scotopic bright-flash electroretinogram and normal dark adaptation.
MedLine Citation:
PMID:  7834567     Owner:  NLM     Status:  MEDLINE    
Recent reports indicate that most subjects with Duchenne muscular dystrophy (DMD) have a negative scotopic bright-flash electroretinogram (ERG). We performed dark adaptometry in seven patients with the DMD phenotype. Three patients had the negative bright-flash response combined with severely reduced rod-related activity; their mean psychophysical dark-adapted threshold was -5.5 +/- 0.3 (normally -5.4 +/- 0.3) cd.m-2. Two of the three patients were able to sit through the complete test: the profile of their dark adaptation curve was normal. The four other patients had a normal scotopic ERG, and their mean psychophysical dark-adapted threshold was -5.3 +/- 0.3 cd.m-2. One of the four was able to complete the entire procedure, and a normal profile was found. In patients with DMD the dark adaptation measurements are normal despite abnormalities in rod-related ERG activity.
F Tremblay; I De Becker; D C Riddell; J M Dooley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie     Volume:  29     ISSN:  0008-4182     ISO Abbreviation:  Can. J. Ophthalmol.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-02-28     Completed Date:  1995-02-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0045312     Medline TA:  Can J Ophthalmol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  280-3     Citation Subset:  IM    
Department of Ophthalmology, Dalhousie University, Halifax, NS.
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MeSH Terms
Dark Adaptation / physiology*
Muscular Dystrophies / physiopathology*
Photic Stimulation
Retinal Rod Photoreceptor Cells / physiology*
Sensory Thresholds / physiology
Visual Perception / physiology

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