| Duchenne muscular dystrophy: alpha-dystroglycan immunoexpression in skeletal muscle and cognitive performance. | |
| | |
MedLine Citation:
|
PMID: 16400417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The Duchenne muscular dystrophy (DMD) is a muscular dystrophy with cognitive impairment present in 20-30% of the cases. In the present study, in order to study the relationship between the alpha-dystroglycan (alpha-DG) immunostaining in skeletal muscle and cognitive performance in DMD patients, 19 were assessed. Twelve patients performed the intelligence quotient (IQ) below the average. Among the 19 patients, two were assessed by the Stanford-Binet test and 17 by Wechsler Intelligence Scale for Children-III (WISC-III). Nine patients performed a verbal IQ below the average, only three patients performed an average verbal IQ. The muscle biopsies immunostained with antibodies to alpha-DG showed that 17 patients presented a low expression, below 25% of the total fibers. Two patients presented alpha-DG immunostaining above 40% and an IQ within the average. No significant statistical relationship was demonstrated among total IQ, verbal IQ and execution IQ and alpha-DG immunostaining at these patients muscle samples. |
| | |
Authors:
|
Conceição Campanario da Silva Pereira; Beatriz Hitomi Kiyomoto; Ricardo Cardoso; Acary Souza Bulle Oliveira |
Related Documents
:
|
9266937 - Increased frequency of somatic mutations at glycophorin a loci in patients with aplasti... 10987867 - Low prevalence of germline cdkn2a and cdk4 mutations in patients with early-onset melan... 17704117 - Therapeutic drug monitoring of the hiv protease inhibitor atazanavir in clinical practice. 19833797 - White matter impairment in rett syndrome: diffusion tensor imaging study with clinical ... 15474747 - In patients with pseudoxanthoma elasticum a thicker and more elastic carotid artery is ... 352087 - Levamisole in multiple sclerosis; with special reference to immunological parameters. a... |
Publication Detail:
|
Type: Journal Article Date: 2005-12-15 |
Journal Detail:
|
Title: Arquivos de neuro-psiquiatria Volume: 63 ISSN: 0004-282X ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 2005 Dec |
Date Detail:
|
Created Date: 2006-01-09 Completed Date: 2006-06-01 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: Brazil |
Other Details:
|
Languages: eng Pagination: 984-9 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil. conceicao.campanario@attglobal.net |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biopsy Child Child, Preschool Cognition Disorders / diagnosis, etiology* Dystroglycans / analysis* Humans Immunohistochemistry Infant Intelligence Tests Muscle, Skeletal / chemistry* Muscular Dystrophy, Duchenne / complications* Stanford-Binet Test Wechsler Scales |
| Chemical | |
Reg. No./Substance:
|
146888-27-9/Dystroglycans |
| Comments/Corrections | |
Erratum In:
|
Arq Neuropsiquiatr. 2006 Mar;64(1):171 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Statistical voxel-wise analysis of ictal SPECT reveals pattern of abnormal perfusion in patients wit...
Next Document: Hemodynamic parameters and neurogenic pulmonary edema following spinal cord injury: an experimental ...