Document Detail


Duchenne muscular dystrophy: alpha-dystroglycan immunoexpression in skeletal muscle and cognitive performance.
MedLine Citation:
PMID:  16400417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Duchenne muscular dystrophy (DMD) is a muscular dystrophy with cognitive impairment present in 20-30% of the cases. In the present study, in order to study the relationship between the alpha-dystroglycan (alpha-DG) immunostaining in skeletal muscle and cognitive performance in DMD patients, 19 were assessed. Twelve patients performed the intelligence quotient (IQ) below the average. Among the 19 patients, two were assessed by the Stanford-Binet test and 17 by Wechsler Intelligence Scale for Children-III (WISC-III). Nine patients performed a verbal IQ below the average, only three patients performed an average verbal IQ. The muscle biopsies immunostained with antibodies to alpha-DG showed that 17 patients presented a low expression, below 25% of the total fibers. Two patients presented alpha-DG immunostaining above 40% and an IQ within the average. No significant statistical relationship was demonstrated among total IQ, verbal IQ and execution IQ and alpha-DG immunostaining at these patients muscle samples.
Authors:
Conceição Campanario da Silva Pereira; Beatriz Hitomi Kiyomoto; Ricardo Cardoso; Acary Souza Bulle Oliveira
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Publication Detail:
Type:  Journal Article     Date:  2005-12-15
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  63     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-09     Completed Date:  2006-06-01     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  984-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil. conceicao.campanario@attglobal.net
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Child
Child, Preschool
Cognition Disorders / diagnosis,  etiology*
Dystroglycans / analysis*
Humans
Immunohistochemistry
Infant
Intelligence Tests
Muscle, Skeletal / chemistry*
Muscular Dystrophy, Duchenne / complications*
Stanford-Binet Test
Wechsler Scales
Chemical
Reg. No./Substance:
146888-27-9/Dystroglycans
Comments/Corrections
Erratum In:
Arq Neuropsiquiatr. 2006 Mar;64(1):171

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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