Document Detail

Duality, thermodynamics, and the linear programming problem in constraint-based models of metabolism.
MedLine Citation:
PMID:  17930409     Owner:  NLM     Status:  MEDLINE    
It is shown that the dual to the linear programming problem that arises in constraint-based models of metabolism can be given a thermodynamic interpretation in which the shadow prices are chemical potential analogues, and the objective is to minimize free energy consumption given a free energy drain corresponding to growth. The interpretation is distinct from conventional nonequilibrium thermodynamics, although it does satisfy a minimum entropy production principle. It can be used to motivate extensions of constraint-based modeling, for example, to microbial ecosystems.
Patrick B Warren; Janette L Jones
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Publication Detail:
Type:  Journal Article     Date:  2007-09-07
Journal Detail:
Title:  Physical review letters     Volume:  99     ISSN:  0031-9007     ISO Abbreviation:  Phys. Rev. Lett.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-12     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401141     Medline TA:  Phys Rev Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  108101     Citation Subset:  IM    
Unilever R&D Port Sunlight, Bebington, Wirral, CH63 3JW, United Kingdom.
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MeSH Terms
Biophysics / methods*
Cytosol / metabolism
Models, Biological
Models, Statistical
Models, Theoretical
Molecular Weight
Systems Biology*

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