| Duality of liver and kidney lesions after systemic infection of immunosuppressed and immunocompetent mice with Aspergillus fumigatus. | |
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MedLine Citation:
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PMID: 22286702 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Invasive aspergillosis is a life-threatening disease mainly caused by Aspergillus fumigatus. Patients at risk are generally immunocompromised and lungs are assumed to provide the primary site for infection and invasive disease manifestation. Contrarily, visceral organ involvement appears to result from a subsequent haematogenous spread. To compare the kinetics of dissemination within deep organs in immunosuppressed versus immunocompetent mice, we used a bioluminescent A. fumigatus strain in an intravenous infection model. By applying an immunosuppressive regimen with corticosteroids, dissemination to the liver and kidneys was observed already 24 hours after inoculation accompanied by a marked inflammatory response within the liver. In contrast, in the immunocompetent condition, fungal growth and inflammation were mainly restricted to the kidneys and only small amounts of fungal biomass and a weak inflammatory response were detected in the liver. Additionally, disease progressed much slower compared to the immunosuppressed condition. This is the first study underlying the duality between liver and renal tropism of A. fumigatus in relation to the immune status of the host. |
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Authors:
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Gregory Jouvion; Matthias Brock; Sabrina Droin-Bergere; Oumaima Ibrahim-Granet |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-01 |
Journal Detail:
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Title: Virulence Volume: 3 ISSN: 2150-5608 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101531386 Medline TA: Virulence Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institut Pasteur; Unité d'Histopathologie Humaine et Modèles Animaux; Paris, France; Université Versailles-Saint Quentin en Yvelines; Faculté de Médecine; DER Histologie; Versailles, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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