| Dual-task conditions modulate the efficiency of selective attention mechanisms in Alzheimer's disease. | |
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MedLine Citation:
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PMID: 20621109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Given previous demonstrations of both selective and divided attention deficits in Alzheimer's disease (AD) patients, understanding how declines in the integrity of component processes of selective attention in these patients interact with impairments to executive processes mediating dual-task performance has both theoretical and practical relevance. To address this issue, healthy elderly and AD patients performed computerized tasks of spatial orienting, Simon response interference, and visual search both in isolation and while simultaneously engaged in a visuomotor tracking task (i.e., maintaining car position within a simulated driving environment). Results from the single-task conditions confirmed previous demonstrations of selective attention deficits in AD. Dual-task conditions produced in AD patients (but not healthy elderly) a change in the efficiency of the selective attention mechanisms themselves, as reflected in differential effects on cue or display conditions within each task. Rather than exacerbating the selective attention deficits observed under single-task conditions, however, dual-task conditions produced an apparent diminution of these deficits. We suggest this diminution is due to the combination of deficient top-down inhibitory processes along with a decrease in the attention-capturing properties of cue information under dual-task conditions in AD patients. These findings not only increase our understanding of the nature of the attentional deficits in AD patients, but also have implications for understanding the processes mediating attention in neurologically intact individuals. |
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Authors:
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Elena K Festa; William C Heindel; Brian R Ott |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-17 |
Journal Detail:
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Title: Neuropsychologia Volume: 48 ISSN: 1873-3514 ISO Abbreviation: Neuropsychologia Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-12-08 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0020713 Medline TA: Neuropsychologia Country: England |
Other Details:
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Languages: eng Pagination: 3252-61 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Cognitive, Linguistic and Psychological Sciences, Brown University, Street, Providence, RI 02912, USA. Elena_Festa@Brown.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / psychology* Attention / physiology* Cognition / physiology Female Humans Linear Models Male Middle Aged Neuropsychological Tests Orientation / physiology Photic Stimulation Psychomotor Performance / physiology Reaction Time / physiology Space Perception / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AG16335/AG/NIA NIH HHS; R01 AG016335-05/AG/NIA NIH HHS; R01 AG016335-09/AG/NIA NIH HHS |
| Comments/Corrections | |
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