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Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of diseases.
MedLine Citation:
PMID:  23190643     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.Genes and Immunity advance online publication, 29 November 2012; doi:10.1038/gene.2012.54.
Authors:
W Wei; Y Jiao; A Postlethwaite; J M Stuart; Y Wang; D Sun; W Gu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-29
Journal Detail:
Title:  Genes and immunity     Volume:  -     ISSN:  1476-5470     ISO Abbreviation:  Genes Immun.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100953417     Medline TA:  Genes Immun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Institute of Endemic Fluorosis Disease, Center for Endemic Disease Control, Center for Disease Control and Prevention, Harbin Medical University, Harbin, PRC [2] Departments of Orthopaedic Surgery and BME, Campbell Clinic, University of Tennessee Health Science Center (UTHSC), Memphis, TN, USA.
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