| Dual-source CT: effect of heart rate, heart rate variability, and calcification on image quality and diagnostic accuracy. | |
| | |
MedLine Citation:
|
PMID: 18372455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To prospectively evaluate the effect of heart rate, heart rate variability, and calcification on dual-source computed tomography (CT) image quality and to prospectively assess diagnostic accuracy of dual-source CT for coronary artery stenosis, by using invasive coronary angiography as the reference standard. MATERIALS AND METHODS: This study had local Ethics Committee approval; all patients gave informed consent. Patients who underwent bypass surgery were excluded; patients with coronary artery stent-grafts were included. One hundred patients (20 women, 80 men; mean age, 62 years +/- 10 [standard deviation]) known to have or suspected of having coronary artery disease underwent dual-source CT and invasive coronary angiography. Image quality was assessed. Accuracy of dual-source CT in depiction or exclusion of significant stenosis (>or=50%) was evaluated on a per-segment and per-patient basis. Effects of heart rate, heart rate variability, and calcification on image quality and accuracy were analyzed by using multivariate regression and were analyzed between subgroups of predictor variables. Simple regression was performed to calculate thresholds for adequate image quality. RESULTS: Mean heart rate was 64.9 beats per minute +/- 13.2, mean variability was 23.6 beats per CT examination +/- 36.2, and mean Agatston score was 786.5 +/- 965.9. Diagnostic image quality was obtained in 90.2% of segments. Sensitivity, specificity, and positive and negative predictive values for the presence of significant stenosis were, respectively, 91.1%, 92.0%, 75.4%, and 97.5% by segment and 100%, 81.5%, 93.6%, and 100% by patient. Image quality was significantly related to heart rate variability (P = .015) and calcification (P < .001); the number of nondiagnostic segments was significantly affected by calcification only. Calcification was the single factor with significant impact on diagnostic accuracy (P = .001). CONCLUSION: While dual-source CT resulted in heart-rate independent image quality, image quality remained prone to heart rate variability and calcification. |
| | |
Authors:
|
Harald Brodoefel; Christof Burgstahler; Ilias Tsiflikas; Anja Reimann; Stephen Schroeder; Claus D Claussen; Martin Heuschmid; Andreas F Kopp |
Related Documents
:
|
1612095 - Fluorine-18 deoxyglucose pet for assessment of viable myocardium in perfusion defects i... 8204395 - Value of thallium-201 early reinjection for assessment of myocardial viability. 7222645 - Thallium 201 scintigraphy. 7671375 - Physiological basis of myocardial contrast enhancement in fast magnetic resonance image... 17901765 - 18f-fdg pet/ct in primary central nervous system lymphoma in hiv-negative patients. 12022095 - Are high-resolution ultrasonographic signs of disc displacement valid? |
Publication Detail:
|
Type: Journal Article Date: 2008-03-27 |
Journal Detail:
|
Title: Radiology Volume: 247 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-04-23 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 346-55 Citation Subset: AIM; IM |
Copyright Information:
|
(c) RSNA, 2008. |
Affiliation:
|
Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str 3, 72076 Tübingen, Germany. h.brodoefel@t-online.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Calcinosis / physiopathology, radiography* Contrast Media Coronary Angiography Coronary Stenosis / physiopathology, radiography* Female Heart Rate / physiology* Humans Iopamidol / analogs & derivatives, diagnostic use Isosorbide Dinitrate / administration & dosage Male Middle Aged Prospective Studies Radiographic Image Interpretation, Computer-Assisted Regression Analysis Sensitivity and Specificity Tomography, X-Ray Computed / methods* Vasodilator Agents / administration & dosage |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Vasodilator Agents; 62883-00-5/Iopamidol; 78649-41-9/iomeprol; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Right heart: split-bolus injection of diluted contrast medium for visualization at coronary CT angio...
Next Document: Radiation dose reduction strategy for CT protocols: successful implementation in neuroradiology sect...