Document Detail


Dual roles for autophagy during follicular atresia in fish ovary.
MedLine Citation:
PMID:  19011378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autophagy, a highly conserved catabolic program for degrading proteins and organelles, is essential for cell and tissue homeostasis. Primarily, this process has a cytoprotective role under nutrient deprivation, but several stress stimuli can induce autophagy and, thus, distinct programmed cell death (PCD) pathways can be actived when stress is not abolished. Fish ovaries are a suitable experimental model system for studying the mechanisms of PCD due to the presence of postovulatory and atretic (i.e., nonovulated) follicles, which follow different routes after spawning. Apoptosis of the follicular cells is the major mechanism responsible for the rapid resorption of the postovulatory follicles. Recently, we investigated the contribution of PCD during follicular atresia in two species of freshwater fish. In contrast to mammals, this study revealed that follicular apoptosis is not a major process for deletion of follicular cells in atretic follicles. Furthermore, we detected autophagic vacuoles containing degenerating organelles increasing through follicular atresia in both species. In this addendum, we propose a hypothesis for follicular cell removal during ovarian regression in oviparous fish. In this model, autophagy could have dual roles in follicular atresia. Thus, fish ovaries after breeding are suitable models for studying the interactions among the different cell death pathways.
Authors:
Ralph G Thomé; Helio B Santos; Fabio P Arantes; Fabrício F T Domingos; Nilo Bazzoli; Elizete Rizzo
Related Documents :
1729388 - Regulation of ovarian steroidogenesis in vitro in the viviparous shark, squalus acanthias.
7943758 - Isolation of granulosa-like cells from the bovine secretory corpus luteum and their cha...
11514338 - Gonadotropin and steroid control of granulosa cell proliferation during the periovulato...
1283178 - Evidence for lipopolysaccharide binding in human granulosa-luteal cells.
8934668 - Biodegradation of phenol by free and immobilized cells of pseudomonas putida.
2670848 - Spreading of cells on various substrates evaluated by fourier analysis of shape.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-30
Journal Detail:
Title:  Autophagy     Volume:  5     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-01-15     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-9     Citation Subset:  IM    
Affiliation:
Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy*
Female
Fishes / physiology*
Follicular Atresia / physiology*
Models, Biological
Ovarian Follicle / cytology,  ultrastructure
Ovary / cytology*,  ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Involvement of PML nuclear bodies in CBP degradation through the ubiquitin-proteasome pathway.
Next Document:  Agreement of blood pressure measurements between random-zero and standard mercury sphygmomanometers.