Document Detail

Dual quantitative coronary angiography: a novel approach to quantify intracoronary thrombotic burden.
MedLine Citation:
PMID:  19284069     Owner:  NLM     Status:  MEDLINE    
AIMS: To validate and test in vivo a new modality of quantitative coronary angiography (QCA), dual QCA (D-QCA), developed to quantify intracoronary thrombotic burden (ITB). METHODS AND RESULTS: Calculation of ITB with D-QCA is based on the discrepancy of luminal areas assessed with edge detection (ED) and video-densitometry (VD), measured with Cardiovascular Angiography Analysis System II. Experimental validation was first performed in phantoms with known obstructive volumes. In vivo assessment of thrombotic burden changes was performed in angiograms from 19 patients with large ITB, obtained before and after antithrombotic treatment, and compared with semi-quantitative assessment (TIMI thrombus grade (TTG)). A good correlation between D-QCA and true occlusive volumes was found (y = 9.21+0.99x, r = 0.996). Intra- and inter-observer variability was 2.77 +/- 10.97 mm3 (p = 0.50) and -1.28 +/- 6.99 mm3 (p = 0.62) respectively. In vivo, D-QCA demonstrated a significant reduction in ITB resulting from treatment (137.22 +/- 120.13 mm3 before and 104.72 +/- 99.19 mm3 after treatment, p = 0.001). Overall, TTG also decreased (3.63 +/- 0.68 before and 3.11 +/- 1.20 after, p = 0.008), but in those nine (47%) patients in which remained unchanged D-QCA detected a reduction in ITB (pre 148.17 +/- 154.03 mm3, post 112.86 +/- 117.82 mm3, p = 0.05). CONCLUSIONS: D-QCA appears as a useful approach to quantify IC thrombus volume, being more sensitive than TTG in assessing changes in ITB resulting from treatment strategies.
Godfrey Aleong; David Vaqueriza; Raquel Del Valle; Hiram Garcia; Rosana Hernandez; Fernando Alfonso; Pilar Jimenez-Quevedo; Camino Bañuelos; Carlos Macaya; Javier Escaned
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  4     ISSN:  1774-024X     ISO Abbreviation:  -     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  France    
Other Details:
Languages:  eng     Pagination:  475-80     Citation Subset:  IM    
Cardiovascular Institute, Hospital Clínico San Carlos, Madrid, Spain.
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MeSH Terms
Aged, 80 and over
Coronary Angiography / instrumentation,  methods*
Coronary Thrombosis / drug therapy*,  radiography*
Fibrinolytic Agents / therapeutic use*
Middle Aged
Observer Variation
Phantoms, Imaging
Predictive Value of Tests
Radiographic Image Interpretation, Computer-Assisted
Reproducibility of Results
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents

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