Document Detail

Dual-probe 24-hour ambulatory pH monitoring for diagnosis of laryngopharyngeal reflux.
MedLine Citation:
PMID:  15638969     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with gastroesophageal reflux disease may suffer from a variety of symptoms from the upper aerodigestive tract. The objective of this study was to determine the impact of dual-probe 24-hr pH monitoring in the diagnosis of reflux-related otolaryngological disorders.
METHODS: Twenty-two patients with symptoms such as chronic cough, globus pharyngeus, heartburn, dysphonia and burning sensation of the tongue underwent a complete ear, nose and throat examination, 24-hr dual-probe pH monitoring, and oesophago-gastro-duodenoscopy.
RESULTS: pH monitoring revealed gastroesophageal (distal) reflux in all patients and pharyngeal (proximal) reflux in 21 patients. Treatment consisted of a proton pump inhibitor (esomeprazole). Within 4 weeks 68 per cent of patients had no laryngopharyngeal symptoms; within 8 weeks 95 per cent of patients were symptom-free.
CONCLUSIONS: Patients with atypical reflux symptoms such as hoarseness, globus sensation or throat-clearing responded well to anti-reflux treatment.
W J Issing; P D Karkos; K Perreas; C Folwaczny; O Reichel
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  118     ISSN:  0022-2151     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2005-01-10     Completed Date:  2005-03-24     Revised Date:  2013-01-07    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  845-8     Citation Subset:  AIM; IM    
Department of Otolaryngology, The Freeman Hospital, Newcastle Upon Tyne NE7 7DN, UK.
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MeSH Terms
Anti-Ulcer Agents / therapeutic use
Cough / etiology
Endoscopy, Gastrointestinal
Esomeprazole Sodium / therapeutic use
Gastroesophageal Reflux / complications,  diagnosis*,  drug therapy
Hoarseness / etiology
Hydrogen-Ion Concentration
Laryngeal Diseases / diagnosis*,  etiology
Middle Aged
Monitoring, Ambulatory / methods*
Reg. No./Substance:
0/Anti-Ulcer Agents; L2C9GWQ43H/Esomeprazole Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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