Document Detail

Dual modulation of the tension of isolated gastric artery and gastric mucosal circulation by hydrogen sulfide in rats.
MedLine Citation:
PMID:  17952370     Owner:  NLM     Status:  MEDLINE    
To clarify roles of H2S in regulation of gastric circulation, we investigated effects of NaHS, a H2S donor, on tension of isolated rat gastric artery and gastric mucosal blood flow in rats. In the precontracted ring preparations, NaHS caused contraction and relaxation at low and high concentrations, respectively. The NaHS-induced vasorelaxation was only partially blocked by glibenclamide, a K+ (ATP) channel inhibitor. The contractile activity of NaHS disappeared by removal of the endothelium or by inhibition of nitric oxide synthase and the endothelium-derived hyperpolarizing factor (EDHF) pathways. Intravenous injection of NaHS caused transient increase followed by decrease in gastric mucosal blood flow in rats. Collectively, in the gastric artery, NaHS appears to cause relaxation through both K+ (ATP) channel-dependent and -independent pathways and contraction through inhibition of NO and EDHF pathways. Together with the in vivo results, our study implies that H2S plays multiple complex roles in regulation of gastric circulation.
S Kubo; M Kajiwara; A Kawabata
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Inflammopharmacology     Volume:  15     ISSN:  0925-4692     ISO Abbreviation:  Inflammopharmacology     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-31     Completed Date:  2008-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112626     Medline TA:  Inflammopharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  288-92     Citation Subset:  IM    
Division of Physiology and Pathophysiology, School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, 577-8502, Japan.
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MeSH Terms
Arteries / drug effects,  physiology*
Biological Factors / physiology
Blood Pressure / drug effects
Endothelium, Vascular / drug effects,  physiology
Gastric Mucosa / blood supply*,  drug effects,  physiology*
Glyburide / pharmacology
Hydrogen Sulfide / pharmacology*
KATP Channels / antagonists & inhibitors
Muscle Contraction / drug effects,  physiology
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects,  physiology
Nitric Oxide Synthase Type III / antagonists & inhibitors
Potassium Channel Blockers / pharmacology
Rats, Wistar
Regional Blood Flow / drug effects,  physiology
Stomach / blood supply*,  drug effects
Reg. No./Substance:
0/Biological Factors; 0/KATP Channels; 0/Potassium Channel Blockers; 0/endothelium-dependent hyperpolarization factor; 10238-21-8/Glyburide; 7783-06-4/Hydrogen Sulfide; EC Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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