| Dual modulation of the tension of isolated gastric artery and gastric mucosal circulation by hydrogen sulfide in rats. | |
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MedLine Citation:
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PMID: 17952370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify roles of H2S in regulation of gastric circulation, we investigated effects of NaHS, a H2S donor, on tension of isolated rat gastric artery and gastric mucosal blood flow in rats. In the precontracted ring preparations, NaHS caused contraction and relaxation at low and high concentrations, respectively. The NaHS-induced vasorelaxation was only partially blocked by glibenclamide, a K+ (ATP) channel inhibitor. The contractile activity of NaHS disappeared by removal of the endothelium or by inhibition of nitric oxide synthase and the endothelium-derived hyperpolarizing factor (EDHF) pathways. Intravenous injection of NaHS caused transient increase followed by decrease in gastric mucosal blood flow in rats. Collectively, in the gastric artery, NaHS appears to cause relaxation through both K+ (ATP) channel-dependent and -independent pathways and contraction through inhibition of NO and EDHF pathways. Together with the in vivo results, our study implies that H2S plays multiple complex roles in regulation of gastric circulation. |
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Authors:
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S Kubo; M Kajiwara; A Kawabata |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Inflammopharmacology Volume: 15 ISSN: 0925-4692 ISO Abbreviation: Inflammopharmacology Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-01-31 Completed Date: 2008-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112626 Medline TA: Inflammopharmacology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 288-92 Citation Subset: IM |
Affiliation:
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Division of Physiology and Pathophysiology, School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, 577-8502, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects, physiology* Biological Factors / physiology Blood Pressure / drug effects Endothelium, Vascular / drug effects, physiology Gastric Mucosa / blood supply*, drug effects, physiology* Glyburide / pharmacology Hydrogen Sulfide / pharmacology* KATP Channels / antagonists & inhibitors Male Muscle Contraction / drug effects, physiology Muscle Relaxation / drug effects Muscle, Smooth, Vascular / drug effects, physiology Nitric Oxide Synthase Type III / antagonists & inhibitors Potassium Channel Blockers / pharmacology Rats Rats, Wistar Regional Blood Flow / drug effects, physiology Stomach / blood supply*, drug effects |
| Chemical | |
Reg. No./Substance:
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0/Biological Factors; 0/KATP Channels; 0/Potassium Channel Blockers; 0/endothelium-dependent hyperpolarization factor; 10238-21-8/Glyburide; 7783-06-4/Hydrogen Sulfide; EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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