| A Dual-inhibition Study on Vascular Smooth Muscle Cells with Meclofenamic Acid and β-irradiation for the Prevention of Restenosis. | |
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MedLine Citation:
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PMID: 21414804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Restenosis is still one of the major limitations after angioplasty. A therapeutic treatment combining β-irradiation and pharmacologic cyclooxygenase-2 inhibition was employed to study the impact on vascular smooth muscle cells (SMCs). MATERIALS AND METHODS: The effects of meclofenamic acid in combination with yttrium-90 ((90)Y) on cell growth, clonogenic activity, cell migration, and cell cycle distribution of human aortic SMCs were investigated. Treatment was sustained over a period of 4 days and recovery of cells was determined until day 20 after initiation. The hypothesis was that there is no difference between control and treated groups. RESULTS: A dose-dependent growth inhibition was observed in single and combined treatment groups for meclofenamic acid and β-irradiation. Cumulative radiation dosage of 8 Gy completely inhibited colony formation. This was also observed for 200 μM meclofenamic acid alone or in combination with minor β-irradiation dosages. Results of the migration tests showed also a dose dependency with additive effects of combined therapy. Meclofenamic acid 200 μM alone and with cumulative β-irradiation dosages resulted in an increased G2/M-phase share. CONCLUSIONS: Incubating human SMCs with meclofenamic acid and (90)Y for a period of 4 d (ie, 1.5 half-life times) resulted in an effective inhibition of smooth muscle cell proliferation, colony formation, and migration. |
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Authors:
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Alexander Sauter; Alexis Landers; Helmut Dittmann; Maren Pritzkow; Benjamin Wiesinger; Melanie Bayer; Rüdiger Bantleon; Jörg Schmehl; Claus D Claussen; Rainer Kehlbach |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: - ISSN: 1535-7732 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, WaldhÖrnlestr. 22, 72072 Tübingen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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