| Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells. | |
| | |
MedLine Citation:
|
PMID: 22796159 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The purpose of this study was to design and evaluate the dual-functional liposome (LPG) with synthetic polymeric nano-biomaterial (Gal-P123) that targets cancer cells and reverses multidrug resistance (MDR) in hepatocellular carcinoma (HCC) cells. The mitoxantrone (MX) loaded LPG (MX-LPG) was about 100 nm in diameter, spherically shaped, and had an encapsulation efficiency of 97.3%. The cytotoxicity and cellular uptake of MX-LPG were evaluated in HCC Huh-7 cells. BCRP-overexpressing MDCKII/BCRP cells were used to certify the inhibitory effect of LPG on drug efflux transporter. Compared with MX, MX-LPG had 2.3-fold higher cytotoxicity in Huh-7 cells and a 14.9-fold increase in cellular MX accumulation in MDCKII/BCRP cells. The pharmacokinetic study in rats showed that LPG significantly prolonged the circulation time and enhanced the bioavailability of MX. Moreover, MX-LPG increased antitumor activity and improved selectivity in BALB/c mice bearing orthotopic xenograft HCC tumors. |
| | |
Authors:
|
Xinxin Zhang; Shiyan Guo; Rong Fan; Miaorong Yu; Feifei Li; Chunliu Zhu; Yong Gan |
Related Documents
:
|
17227579 - Directed cell migration in the presence of obstacles. 20614479 - Interstitial cells of cajal, the maestro in health and disease. 20201409 - Formation of multicellular aggregates under different conditions of microenvironment. 6850839 - The organisation of fruiting body formation in dictyostelium minutum. 9226449 - A novel prespore-cell-inducing factor in dictyostelium discoideum induces cell division... 10320939 - Organization and polarity of actin filament networks in cells: implications for the mec... 72829 - Supravital staining of spermatozoa: relationship of eosin concentration to the percenta... 3091949 - Improved detection of terminal transferase (tdt): the use of detergents on glutaraldehy... 2925799 - Effects of 1,25-dihydroxyvitamin d3 on cell-cycle kinetics of t 47d human breast cancer... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-12 |
Journal Detail:
|
Title: Biomaterials Volume: - ISSN: 1878-5905 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Simultaneous nuclear imaging and intranuclear drug delivery by nuclear-targeted multifunctional upco...
Next Document: A review of nanocarriers for the delivery of small interfering RNA.