Document Detail

Dual energy CT for the assessment of reperfused chronic infarction - a feasibility study in a porcine model.
MedLine Citation:
PMID:  21873508     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Detection of myocardial infarction has been the focus of considerable research over the past few decades. Recently developed dual source computed tomography (DSCT) scanners with dual energy mode have been used to detect myocardial infarction, but the studies on this topic are few.
PURPOSE: To evaluate the feasibility and performance of dual energy CT (DECT) during arterial phase in coronary CT angiography for the detection of chronic infarction compared with late enhancement MRI (LE-MRI) and histopathology in a porcine model of reperfused myocardial infarction.
MATERIAL AND METHODS: Myocardial infarctions were induced by 30 min occlusion of the proximal left anterior descending coronary artery in eight minipigs. DECT, post-contrast LE-MRI and histopathology were performed 60 days after infarct induction. The CT scan was performed in dual energy mode using a dedicated protocol. Myocardial iodine distribution was superimposed as color maps on grey scale multiplanar reformats of the heart. Two radiologists in consensus interpreted all imaging studies for presence of gadolinium uptake at LE-MRI reduced iodine content at DECT and hypoenhanced areas in the initial 100 kV coronary CT angiography images that were acquired during the DECT-acquisition. Results were compared with histopathology.
RESULTS: Based on evaluable segments, DECT showed a sensitivity and specificity of 0.72 and 0.88; LE-MRI showed a sensitivity and specificity of 0.78 and 0.92; and the 100 kV data-set of the DECT scan showed a sensitivity and specificity of 0.60 and 0.93, respectively, for the detection of histological proved ischemia.
CONCLUSION: DECT during arterial phase coronary CT angiography, which is ordinarily used for coronary artery evaluation, is feasible for the detection of a chronic reperfused myocardial infarction.
J Matthias Kerl; Simon Deseive; Christa Tandi; Christina Kaiser; Mattias Kettner; Huedayi Korkusuz; Ralf Lehmann; Christopher Herzog; U Joseph Schoepf; Thomas J Vogl; Ralf W Bauer
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-08-26
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  52     ISSN:  1600-0455     ISO Abbreviation:  Acta Radiol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2011-12-05     Revised Date:  2012-11-09    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  834-9     Citation Subset:  IM    
Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University, Frankfurt, Germany.
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MeSH Terms
Chronic Disease
Contrast Media / diagnostic use
Disease Models, Animal
Feasibility Studies
Magnetic Resonance Imaging
Myocardial Infarction / pathology,  radiography*
Myocardial Reperfusion
Sensitivity and Specificity
Swine, Miniature
Tomography, X-Ray Computed / methods*
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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