Document Detail


Dual enantioselective effect of the insecticide bifenthrin on locomotor behavior and development in embryonic-larval zebrafish.
MedLine Citation:
PMID:  20821606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bifenthrin (BF) is a synthetic pyrethroid that targets the nervous system of insects and may have adverse effects on the behavior and development of nontarget organisms. However, no reports have been issued on the effects of different enantiomers on locomotor behavior for synthetic pyrethroids (SPs) in zebrafish, and whether locomotor activity is associated with the developmental toxicities remains unclear. In this study, enantioselectivity of BF (1S and 1R) on the acute locomotor activity and developmental toxicities of embryonic-larval zebrafish were first evaluated. The results indicated that 1R-BF was more toxic, causing morphological impairments, with a 96-h median effective concentration (EC50) of 226 microg/L for pericardial edema and 145 microg/L for curved body axis. Administration of 20 microg/L of one enantiomer of BF had differential effects on the locomotor activity of zebrafish larvae at 4 d postfertilization (dpf) under alternating light and dark conditions. Larvae treated with 1R-BF were not sensitive to the alteration of light to dark, and the locomotor activities were reduced to a level similar to that observed in light, which otherwise increased rapidly and markedly. However, 1S-BF did not alter the general pattern of zebrafish response to the light or dark compared with the control. The results demonstrated that the differential effects on development might have contributed to the enantioselectivity in the locomotor activity. The consistency of enantioselectivity with insecticidal activity may also indicate a common mode of action. Furthermore, 1R-BF accelerated the spontaneous movement and hatching process, whereas 1S-BF seemed to be inhibitory. The results suggest the need to link behavioral changes to developmental toxicities in order to achieve more comprehensive health risk assessments of chiral pesticides.
Authors:
Meiqing Jin; Ying Zhang; Jing Ye; Changjiang Huang; Meirong Zhao; Weiping Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  29     ISSN:  1552-8618     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-09-07     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1561-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 SETAC.
Affiliation:
MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Zhejiang University, Hangzhou 310027, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Insecticides / toxicity*
Larva / drug effects*,  physiology
Locomotion / drug effects*
Pyrethrins / toxicity*
Stereoisomerism
Zebrafish / growth & development,  physiology*
Chemical
Reg. No./Substance:
0/Insecticides; 0/Pyrethrins; 82657-04-3/bifenthrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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