Document Detail


Dual effects of gadodiamide injection in depiction of the region of myocardial ischemia.
MedLine Citation:
PMID:  8428089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The high safety index of the nonionic magnetic resonance (MR) contrast agent gadodiamide injection permits a wide dose range without induction of hemodynamic effects. The wide dose range might confer a diagnostic advantage by providing both T1 enhancing and magnetic susceptibility effects for demarcating pathologic regions. The dual utility of this contrast agent for T1 and T2 enhancement in creating differential contrast between normal and acutely ischemic myocardium was explored. MR imaging was initiated 20-40 minutes after occlusion of the left coronary artery in two groups of rats: Group 1 (n = 8) received 0.3 mmol/kg gadodiamide injection before and after acquisition of T1-weighted images; group 2 (n = 10) received 0.5 mmol/kg before and after acquisition of T2-weighted images. Postcontrast T1-weighted images showed clear delineation of the ischemic region as a relatively low-signal-intensity area for 15 minutes. On postcontrast T2-weighted images, the ischemic region appeared as a relatively high-signal-intensity area for 60 minutes. These effects were obtained with doses of gadodiamide injection that have safety indexes greater than those of gadopentetate dimeglumine.
Authors:
M Saeed; M F Wendland; K K Yu; H T Li; C B Higgins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  3     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:    1993 Jan-Feb
Date Detail:
Created Date:  1993-03-09     Completed Date:  1993-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of California, San Francisco 94143.
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MeSH Terms
Descriptor/Qualifier:
Animals
Contrast Media
Dose-Response Relationship, Drug
Female
Gadolinium / diagnostic use*
Gadolinium DTPA*
Image Enhancement / methods
Image Processing, Computer-Assisted
Magnetic Resonance Imaging*
Myocardial Ischemia / diagnosis*
Myocardium / pathology*
Organometallic Compounds / diagnostic use*
Pentetic Acid / diagnostic use*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 122795-43-1/gadodiamide; 67-43-6/Pentetic Acid; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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