Document Detail


Dual effects of ATP on isolated arteries of the bovine eye.
MedLine Citation:
PMID:  22521505     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although the presence of purinoreceptors has been shown in many human and animal arteries, there is few data yet about their role in the arteries of the eye. The purpose of the present study was to evaluate the effects of several agonists of purinoreceptors on isolated arteries of the bovine eye. Responses of isolated preparations of bovine ophthalmic (OA) and posterior ciliary arteries (PCA) to agonists of purinoreceptors (ATP, α,β-methylene-ATP-α,β-meATP, 2-methylthioATP-2meSATP, uridine-5'-triphosphate-UTP) as well as agonists of adreno-, cholino-, adenosine and histamine receptors were recorded by a standard organ bath method. ATP induced contractions of the intact vessels but caused relaxation of α,β-meATP-pretreated arteries. Contractile responses of PCA to high concentrations of ATP and α,β-meATP were significantly stronger than responses of OA, as well as relaxative responses to ATP and adenosine were significantly stronger in PCA than in OA. We suggest that there are several subtypes of functionally active purinoreceptors in both OA and PCA, although the potency of agonists of purinoreceptors to produce mechanical responses is higher in PCA than in OA. Purinoreceptors can be potential targets for new drugs, treating vascular pathology of the eye.
Authors:
Anna P Ziganshina; Bulat A Ziganshin; Ayrat U Ziganshin
Related Documents :
15652915 - A uterine cavity-myoma communication after uterine artery embolization: two case reports.
2927855 - Correlation of apgar scores and umbilical artery acid-base status to mortality and morb...
12066945 - Altered vascular function in healthy normotensive pregnant women with bilateral uterine...
9933695 - Distal pulse palpation: is it reliable?
7414945 - Morphometry of intrarenal arteries in progressive sclerosis.
22558515 - Risk factors for persistent pulmonary hypertension of the newborn.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-10
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  -     ISSN:  1096-1186     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Kazan State Medical University, 49 Butlerov Str., Kazan 420012, Russia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pilot study of denileukin diftitox alternate dosing regimen in patients with cutaneous peripheral T-...
Next Document:  Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor...