| Dual effect of statin medication on the periodontium. | |
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MedLine Citation:
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PMID: 19930091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study was to investigate the association between statin medication and periodontal infection in an adult population. MATERIAL AND METHODS: The study was based on a subpopulation of the Health 2000 Survey, which included dentate non-diabetic, non-rheumatic subjects who did not smoke, aged 40-69 years (n=2032). The main outcome variable was the number of teeth with periodontal pockets of 4 mm or more. Statin medication was categorized in two ways: firstly, subjects with statin medication of some sort (n=134) versus those with none, and secondly, subjects taking either simvastatin (n=58), atorvastatin (n=38), some other statin (n=38) or no statin medication. Relative risks (RR) were estimated using negative binomial and Poisson regression models. RESULTS: We found a weak negative association between statin medication and periodontal infection among subjects with dental plaque or gingival bleeding. Among subjects with no gingival bleeding, statin medication was found to be associated with an increased likelihood of having deepened periodontal pockets. CONCLUSION: Statin medication appears to have an effect on the periodontium that is dependent on the inflammatory condition of the periodontium. More evidence is needed to achieve a comprehensive understanding of the effects of statins. |
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Authors:
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Tuomas Saxlin; Liisa Suominen-Taipale; Matti Knuuttila; Pirkko Alha; Pekka Yl?stalo |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical periodontology Volume: 36 ISSN: 1600-051X ISO Abbreviation: J. Clin. Periodontol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425123 Medline TA: J Clin Periodontol Country: Denmark |
Other Details:
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Languages: eng Pagination: 997-1003 Citation Subset: D; IM |
Affiliation:
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Institute of Dentistry, University of Oulu, Oulu, Finland. tuomas.saxlin@oulu.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticholesteremic Agents / adverse effects*, therapeutic use* Dental Plaque / complications Female Gingivitis / complications Heptanoic Acids / adverse effects, therapeutic use Humans Immunomodulation Male Middle Aged Periodontal Index Periodontal Pocket / etiology*, prevention & control* Periodontium / drug effects* Pyrroles / adverse effects, therapeutic use Regression Analysis Risk Factors Simvastatin / adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Heptanoic Acids; 0/Pyrroles; 110862-48-1/atorvastatin; 79902-63-9/Simvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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