| Dual actions of fibroblast growth factor 19 on lipid metabolism. | |
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MedLine Citation:
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PMID: 23204296 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Elevated triglyceride and cholesterol levels are risk factors for cardiovascular disease and are often associated with diabetes and metabolic syndrome. Recent reports suggest that FGF19 and FGF21 can dramatically improve metabolic dysfunction, including hyperglycemia, hypertriglyceridemia, and hypercholesterolemia. Due to their similar receptor specificities and co-receptor requirements, FGF19 and FGF21 share many common properties and have been thought to be interchangeable in metabolic regulation. Here we directly compared how pharmacological administration of recombinant FGF19 or FGF21 proteins affect metabolism in the B6.V-Lepob/J leptin deficient mice. FGF19 and FGF21 equally improved glucose parameters, however, we observed increased serum triglyceride and cholesterol levels after treatment with FGF19, but not with FGF21. Increases in serum triglycerides levels were also observed after a 4-day treatment with FGF19 in C57BL6/J mice on high fat diet. This is in contrast to many literature reports which showed significant improvements in hyperlipidemia after chronic treatment with either FGF19 or FGF21 in high fed diet models. We propose that FGF19 has both lipid raising and lipid lowering actions mediated through different FGF receptors and target tissues, and results described here provide a potential mechanism that may explain the inconsistency in the reported effects of FGF19 on lipid metabolism. |
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Authors:
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Xinle Wu; Hongfei Ge; Helene Baribault; Jamila Gupte; Jennifer Weiszmann; Bryan Lemon; Jonitha Gardner; Preston Fordstrom; Jie Tang; Mingyue Zhou; Minghan Wang; Yang Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-2 |
Journal Detail:
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Title: Journal of lipid research Volume: - ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Amgen Inc., United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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